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- W60964221 abstract "ZusammenfassungThe relationship between estrogen deficiency and osteoporosis was first formally described in the 1940s. Since then, the biologic relationship between estrogen deficiency and bone loss has been explored in detail. With the onset of estrogen deficiency, increased activation of bone remodeling is seen at the bone histomorphometric level, with a consequent increase in biochemical markers of bone remodeling in blood and urine, Bone loss occurs most rapidly in the first 5 years after overt menopause, especially at cancellous bone sites, but estrogendependent bone loss cotinues thoughout life. Mechanisms include increased monocyte and osteoblast production of a variety of cytokines, including tumor necrosis factor (TNF), interleukin-1 (IL-1), IL-6, and the receptor activator of nuclear factor κB ligand (RANKL), among others, all of which promote osteoclastogenesis and osteoclast activity, the first event in the remodeling process. In addition to an increased remodeling rate, permanent loss of bone tissue requires an imbalance between bone formation and resorption, with a net loss of bone occurring during each remodeling cycle." @default.
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- W60964221 date "2003-01-01" @default.
- W60964221 modified "2023-09-25" @default.
- W60964221 title "Estrogen-dependent Bone Loss and Osteoporosis" @default.
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- W60964221 doi "https://doi.org/10.1007/978-1-4757-4561-0_9" @default.
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