Matches in SemOpenAlex for { <https://semopenalex.org/work/W610307525> ?p ?o ?g. }
- W610307525 abstract "Abstract The present study aimed to detect the role of 3, 4-dihydroxyl-phenyl lactic acid (DLA) during ischemia/reperfusion (I/R) induced myocardial injury with emphasis on the underlying mechanism of DLA antioxidant. Male Spragu-Dawley (SD) rats were subjected to left descending artery occlusion followed by reperfusion. Treatment with DLA ameliorated myocardial structure and function disorder, blunted the impairment of Complex I activity and mitochondrial function after I/R. The results of 2-D fluorescence difference gel electrophoresis revealed that DLA prevented the decrease in NDUFA10 expression, one of the subunits of Complex I. To find the target of DLA, the binding affinity of Sirtuin 1 (SIRT1) to DLA and DLA derivatives with replaced two phenolic hydroxyls was detected using surface plasmon resonance and bilayer interferometry. The results showed that DLA could activate SIRT1 after I/R probably by binding to this protein, depending on phenolic hydroxyl. Moreover, the importance of SIRT1 to DLA effectiveness was confirmed through siRNA transfection in vitro . These results demonstrated that DLA was able to prevent I/R induced decrease in NDUFA10 expression, improve Complex I activity and mitochondrial function, eventually attenuate cardiac structure and function injury after I/R, which was possibly related to its ability of binding to and activating SIRT1." @default.
- W610307525 created "2016-06-24" @default.
- W610307525 creator A5000095164 @default.
- W610307525 creator A5012307033 @default.
- W610307525 creator A5014609476 @default.
- W610307525 creator A5033415932 @default.
- W610307525 creator A5037803523 @default.
- W610307525 creator A5042115463 @default.
- W610307525 creator A5048399715 @default.
- W610307525 creator A5054672150 @default.
- W610307525 creator A5056636431 @default.
- W610307525 creator A5063161253 @default.
- W610307525 creator A5065350957 @default.
- W610307525 creator A5065587658 @default.
- W610307525 creator A5069984943 @default.
- W610307525 creator A5072623207 @default.
- W610307525 creator A5080658884 @default.
- W610307525 creator A5084545866 @default.
- W610307525 creator A5086949810 @default.
- W610307525 creator A5091276160 @default.
- W610307525 date "2015-06-01" @default.
- W610307525 modified "2023-10-16" @default.
- W610307525 title "3, 4-dihydroxyl-phenyl lactic acid restores NADH dehydrogenase 1 α subunit 10 to ameliorate cardiac reperfusion injury" @default.
- W610307525 cites W1757449048 @default.
- W610307525 cites W1965255694 @default.
- W610307525 cites W1970916286 @default.
- W610307525 cites W1972678080 @default.
- W610307525 cites W1978294146 @default.
- W610307525 cites W1979269047 @default.
- W610307525 cites W1987296005 @default.
- W610307525 cites W2023714210 @default.
- W610307525 cites W2028102963 @default.
- W610307525 cites W2040725645 @default.
- W610307525 cites W2043355876 @default.
- W610307525 cites W2049108687 @default.
- W610307525 cites W2052866387 @default.
- W610307525 cites W2053045499 @default.
- W610307525 cites W2059477502 @default.
- W610307525 cites W2071203027 @default.
- W610307525 cites W2087019732 @default.
- W610307525 cites W2094303056 @default.
- W610307525 cites W2102409753 @default.
- W610307525 cites W2102584184 @default.
- W610307525 cites W2104648406 @default.
- W610307525 cites W2109004272 @default.
- W610307525 cites W2109202682 @default.
- W610307525 cites W2118204731 @default.
- W610307525 cites W2118964113 @default.
- W610307525 cites W2121966499 @default.
- W610307525 cites W2123016403 @default.
- W610307525 cites W2124898423 @default.
- W610307525 cites W2135387645 @default.
- W610307525 cites W2139639947 @default.
- W610307525 cites W2142397871 @default.
- W610307525 cites W2144600435 @default.
- W610307525 cites W2150494811 @default.
- W610307525 cites W2152365387 @default.
- W610307525 cites W2160414137 @default.
- W610307525 cites W2162151881 @default.
- W610307525 cites W2168890097 @default.
- W610307525 cites W2172133607 @default.
- W610307525 cites W2210401360 @default.
- W610307525 cites W2271272206 @default.
- W610307525 cites W299699636 @default.
- W610307525 doi "https://doi.org/10.1038/srep10739" @default.
- W610307525 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5377067" @default.
- W610307525 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26030156" @default.
- W610307525 hasPublicationYear "2015" @default.
- W610307525 type Work @default.
- W610307525 sameAs 610307525 @default.
- W610307525 citedByCount "29" @default.
- W610307525 countsByYear W6103075252016 @default.
- W610307525 countsByYear W6103075252017 @default.
- W610307525 countsByYear W6103075252018 @default.
- W610307525 countsByYear W6103075252019 @default.
- W610307525 countsByYear W6103075252020 @default.
- W610307525 countsByYear W6103075252021 @default.
- W610307525 countsByYear W6103075252022 @default.
- W610307525 countsByYear W6103075252023 @default.
- W610307525 crossrefType "journal-article" @default.
- W610307525 hasAuthorship W610307525A5000095164 @default.
- W610307525 hasAuthorship W610307525A5012307033 @default.
- W610307525 hasAuthorship W610307525A5014609476 @default.
- W610307525 hasAuthorship W610307525A5033415932 @default.
- W610307525 hasAuthorship W610307525A5037803523 @default.
- W610307525 hasAuthorship W610307525A5042115463 @default.
- W610307525 hasAuthorship W610307525A5048399715 @default.
- W610307525 hasAuthorship W610307525A5054672150 @default.
- W610307525 hasAuthorship W610307525A5056636431 @default.
- W610307525 hasAuthorship W610307525A5063161253 @default.
- W610307525 hasAuthorship W610307525A5065350957 @default.
- W610307525 hasAuthorship W610307525A5065587658 @default.
- W610307525 hasAuthorship W610307525A5069984943 @default.
- W610307525 hasAuthorship W610307525A5072623207 @default.
- W610307525 hasAuthorship W610307525A5080658884 @default.
- W610307525 hasAuthorship W610307525A5084545866 @default.
- W610307525 hasAuthorship W610307525A5086949810 @default.
- W610307525 hasAuthorship W610307525A5091276160 @default.
- W610307525 hasBestOaLocation W6103075251 @default.
- W610307525 hasConcept C104292427 @default.