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- W61046066 abstract "This chapter discusses recent developments made in neuropeptide Y (NPY) receptor modulators research. NPY is a 36 amino acid neuropeptide that is widely distributed in both the central and peripheral nervous systems and is one of the most abundant neuropeptides identified to date. NPY is a member of the pancreatic polypeptide family including structurally related peptides, peptide YY (PYY), and pancreatic polypeptide (PP). Scientific investigation in the past 20 years has generated a large body of knowledge about the biology of NPY, and it is now known that NPY is involved in a broad spectrum of physiological systems. The effects of NPY are mediated by several G protein-coupled receptors that have been designated as Y1, Y2, Y3, Y4, Y5, and Y6. These receptors share only modest primary sequence homology (30–50%) and have unique tissue localizations. The chapter briefly describes the role that NPY and its receptors play in these physiological systems. It summarizes the status of drug discovery in the NPY field and elaborates the potential therapeutic applications of NPY." @default.
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- W61046066 date "2003-01-01" @default.
- W61046066 modified "2023-09-24" @default.
- W61046066 title "Chapter 7. Recent developments in neuropeptide Y receptor modulators" @default.
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- W61046066 doi "https://doi.org/10.1016/s0065-7743(03)38008-x" @default.
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