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• W61076593 abstract "Event Abstract Back to Event Fos activation in the lower brainstem after feeding and refeeding in gold thioglucose-treated mice Péter Kurucz1*, Kinga Ibolya1, Meltzer K. Szabó1 and Miklos Palkovits1 1 Hungarian Academy of Sciences and Semmelweis University, Hungary Single injection of gold thioglucose (GTG) lesions the hypothalamic ventromedial nucleus in mice and increases food intake and obesity. It is also known that GTG treatment produces lesions in the lower brainstem as well: in the nucleus of the solitary tract (NTS), the dorsal motor nucleus of vagus (DMV) and the area postrema (AP). In the present study, acute responses to fasting and refeeding were investigated by immunohistochemical detection of Fos expression in neurons located in these brain areas of GTG lesioned and control mice. Very strong Fos activity was seen in the DMV and AP in control mice after 2 days fasting, while the NTS was silent. GTG-treated, fasted animals showed similar pattern of Fos distribution but with reduced number of immunoreactive neurons in all three investigated nuclei. In control mice, refeeding increased Fos activity in the NTS and AP while the DMV remained silent. In GTG-treated mice, feeding produced Fos immunoreactivity in the same areas but the intensity was lower than that in saline-injected control mice. In summary, refeeding elicited activity in the nucleus of the solitary tract and the area postrema neurons was reduced by GTG. In GTG-treated animals fasting produced lower intensity changes in the activity of the preganglionic dorsal motor vagal neurons but not in the viscerosensory NTS. These results are similar to our previous findings concerning on the effect of fasting and refeeding in the vagal nuclei of monosodium glutamate treated rats. Supported by OTKA K 62893. Conference: 12th Meeting of the Hungarian Neuroscience Society, Budapest, Hungary, 22 Jan - 24 Jan, 2009. Presentation Type: Poster Presentation Topic: Homeostatic regulatory mechanisms Citation: Kurucz P, Ibolya K, Szabó MK and Palkovits M (2009). Fos activation in the lower brainstem after feeding and refeeding in gold thioglucose-treated mice. Front. Syst. Neurosci. Conference Abstract: 12th Meeting of the Hungarian Neuroscience Society. doi: 10.3389/conf.neuro.01.2009.04.114 Copyright: The abstracts in this collection have not been subject to any Frontiers peer review or checks, and are not endorsed by Frontiers. They are made available through the Frontiers publishing platform as a service to conference organizers and presenters. The copyright in the individual abstracts is owned by the author of each abstract or his/her employer unless otherwise stated. Each abstract, as well as the collection of abstracts, are published under a Creative Commons CC-BY 4.0 (attribution) licence (https://creativecommons.org/licenses/by/4.0/) and may thus be reproduced, translated, adapted and be the subject of derivative works provided the authors and Frontiers are attributed. For Frontiers’ terms and conditions please see https://www.frontiersin.org/legal/terms-and-conditions. Received: 04 Mar 2009; Published Online: 04 Mar 2009. * Correspondence: Péter Kurucz, Hungarian Academy of Sciences and Semmelweis University, Budapest, Hungary, kuruczp@gmail.com Login Required This action requires you to be registered with Frontiers and logged in. To register or login click here. Abstract Info Abstract The Authors in Frontiers Péter Kurucz Kinga Ibolya Meltzer K Szabó Miklos Palkovits Google Péter Kurucz Kinga Ibolya Meltzer K Szabó Miklos Palkovits Google Scholar Péter Kurucz Kinga Ibolya Meltzer K Szabó Miklos Palkovits PubMed Péter Kurucz Kinga Ibolya Meltzer K Szabó Miklos Palkovits Related Article in Frontiers Google Scholar PubMed Abstract Close Back to top Javascript is disabled. Please enable Javascript in your browser settings in order to see all the content on this page." @default.
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• W61076593 title "Fos activation in the lower brainstem after feeding and refeeding in gold thioglucose-treated mice" @default.
• W61076593 doi "https://doi.org/10.3389/conf.neuro.01.2009.04.114" @default.
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