Matches in SemOpenAlex for { <https://semopenalex.org/work/W61098746> ?p ?o ?g. }
Showing items 1 to 100 of
100
with 100 items per page.
- W61098746 endingPage "349" @default.
- W61098746 startingPage "341" @default.
- W61098746 abstract "Alzheimer's disease (AD) is a progressive neurodegenerative disorder that shows cognitive deficits and memory impairment. Extract from the leaves of Gotu Kola (Centella Asiatica) have been used as an alternative medicine for memory improvement in Indian Ayurvedic system of medicine for a long time. Although several studies have revealed its effect in ameliorating the cognitive impairment in rat models of AD and stimulating property on neuronal dendrites of hippocampal region, the molecular mechanism of Gotu Kola on neuroprotection still remains to be elucidated. In this study, we report that phosphorylation of cyclic AMP response element binding protein (CREB) is enhanced in both a neuroblastoma cell line expressing amyloid beta 1-42 (Abeta) and in rat embryonic cortical primary cell culture. In addition, the contribution of two major single components to the enhanced CREB phosphorylatioin was examined. Furthermore, inhibitors were applied in this study revealing that ERK/RSK signaling pathway might mediate this effect of Gotu Kola extract. Taken together, we provide a possible molecular mechanism for memory enhancing property of Gotu Kola extract for the first time." @default.
- W61098746 created "2016-06-24" @default.
- W61098746 creator A5003791840 @default.
- W61098746 creator A5004736209 @default.
- W61098746 creator A5005519160 @default.
- W61098746 creator A5049082763 @default.
- W61098746 date "2008-04-14" @default.
- W61098746 modified "2023-09-26" @default.
- W61098746 title "Gotu Kola (Centella Asiatica) Extract Enhances Phosphorylation of Cyclic AMP Response Element Binding Protein in Neuroblastoma Cells Expressing Amyloid Beta Peptide" @default.
- W61098746 doi "https://doi.org/10.3233/jad-2008-13311" @default.
- W61098746 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18431001" @default.
- W61098746 hasPublicationYear "2008" @default.
- W61098746 type Work @default.
- W61098746 sameAs 61098746 @default.
- W61098746 citedByCount "46" @default.
- W61098746 countsByYear W610987462012 @default.
- W61098746 countsByYear W610987462013 @default.
- W61098746 countsByYear W610987462014 @default.
- W61098746 countsByYear W610987462015 @default.
- W61098746 countsByYear W610987462016 @default.
- W61098746 countsByYear W610987462017 @default.
- W61098746 countsByYear W610987462018 @default.
- W61098746 countsByYear W610987462019 @default.
- W61098746 countsByYear W610987462020 @default.
- W61098746 countsByYear W610987462021 @default.
- W61098746 countsByYear W610987462022 @default.
- W61098746 countsByYear W610987462023 @default.
- W61098746 crossrefType "journal-article" @default.
- W61098746 hasAuthorship W61098746A5003791840 @default.
- W61098746 hasAuthorship W61098746A5004736209 @default.
- W61098746 hasAuthorship W61098746A5005519160 @default.
- W61098746 hasAuthorship W61098746A5049082763 @default.
- W61098746 hasConcept C104317684 @default.
- W61098746 hasConcept C11960822 @default.
- W61098746 hasConcept C126322002 @default.
- W61098746 hasConcept C144027150 @default.
- W61098746 hasConcept C1629964 @default.
- W61098746 hasConcept C169760540 @default.
- W61098746 hasConcept C185592680 @default.
- W61098746 hasConcept C25498285 @default.
- W61098746 hasConcept C2776156579 @default.
- W61098746 hasConcept C2777633098 @default.
- W61098746 hasConcept C2778670691 @default.
- W61098746 hasConcept C2779077069 @default.
- W61098746 hasConcept C2779134260 @default.
- W61098746 hasConcept C2779281246 @default.
- W61098746 hasConcept C502032728 @default.
- W61098746 hasConcept C55493867 @default.
- W61098746 hasConcept C57074206 @default.
- W61098746 hasConcept C59822182 @default.
- W61098746 hasConcept C71924100 @default.
- W61098746 hasConcept C86339819 @default.
- W61098746 hasConcept C86803240 @default.
- W61098746 hasConcept C95444343 @default.
- W61098746 hasConcept C98274493 @default.
- W61098746 hasConceptScore W61098746C104317684 @default.
- W61098746 hasConceptScore W61098746C11960822 @default.
- W61098746 hasConceptScore W61098746C126322002 @default.
- W61098746 hasConceptScore W61098746C144027150 @default.
- W61098746 hasConceptScore W61098746C1629964 @default.
- W61098746 hasConceptScore W61098746C169760540 @default.
- W61098746 hasConceptScore W61098746C185592680 @default.
- W61098746 hasConceptScore W61098746C25498285 @default.
- W61098746 hasConceptScore W61098746C2776156579 @default.
- W61098746 hasConceptScore W61098746C2777633098 @default.
- W61098746 hasConceptScore W61098746C2778670691 @default.
- W61098746 hasConceptScore W61098746C2779077069 @default.
- W61098746 hasConceptScore W61098746C2779134260 @default.
- W61098746 hasConceptScore W61098746C2779281246 @default.
- W61098746 hasConceptScore W61098746C502032728 @default.
- W61098746 hasConceptScore W61098746C55493867 @default.
- W61098746 hasConceptScore W61098746C57074206 @default.
- W61098746 hasConceptScore W61098746C59822182 @default.
- W61098746 hasConceptScore W61098746C71924100 @default.
- W61098746 hasConceptScore W61098746C86339819 @default.
- W61098746 hasConceptScore W61098746C86803240 @default.
- W61098746 hasConceptScore W61098746C95444343 @default.
- W61098746 hasConceptScore W61098746C98274493 @default.
- W61098746 hasIssue "3" @default.
- W61098746 hasLocation W610987461 @default.
- W61098746 hasLocation W610987462 @default.
- W61098746 hasOpenAccess W61098746 @default.
- W61098746 hasPrimaryLocation W610987461 @default.
- W61098746 hasRelatedWork W2003459185 @default.
- W61098746 hasRelatedWork W2025770620 @default.
- W61098746 hasRelatedWork W2040572577 @default.
- W61098746 hasRelatedWork W2052362558 @default.
- W61098746 hasRelatedWork W2054686427 @default.
- W61098746 hasRelatedWork W2138274967 @default.
- W61098746 hasRelatedWork W2527458594 @default.
- W61098746 hasRelatedWork W2561896435 @default.
- W61098746 hasRelatedWork W2909025052 @default.
- W61098746 hasRelatedWork W61098746 @default.
- W61098746 hasVolume "13" @default.
- W61098746 isParatext "false" @default.
- W61098746 isRetracted "false" @default.
- W61098746 magId "61098746" @default.
- W61098746 workType "article" @default.