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- W611234513 abstract "The distribution of the al' a2 and ~2/3subunits of the GABAA receptor in the anterior thalamus of the rat was studied by immunocytochemistry using subunit-specific antibodies. In general, though with some exceptions, immunoreactivity was observed mostly in the neuropil. Most prin cipal (relay) thalamic nuclei showed strong al and ~2/3-positivity; however, most intralaminar nuclei were immunonegative for these subunits. The reverse was true of a? immunoreactivity: most intralaminar nuclei were strongly a?-positive, whereas most principal nuclei were cl?-nega tive or only weakly immunopositive. These data suggest that neurons in the principal nuclei mostly express GABAA receptors containing the aland ~2! subunits (i.e. benzodiazepine type 1 receptors), while neurons in the intralaminar nu clei mostly express GABAA receptors containing the a? subunit (i.e. benzodiazepine type II re ceptors). Double-Iabeling experiments revealed colocalization of the al and ~2/3 subunits insomata and neurites of most principal nuclei. Colocalization of the al and a2 subunits was observed only in neurons of the anterodorsal nucleus." @default.
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- W611234513 date "2020-09-22" @default.
- W611234513 modified "2023-10-06" @default.
- W611234513 title "Distribution of the a 1 , a 2 and B 2/3 GABA A receptor subunits in the anterior thalamus of the rat" @default.
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