Matches in SemOpenAlex for { <https://semopenalex.org/work/W61176992> ?p ?o ?g. }
Showing items 1 to 66 of
66
with 100 items per page.
- W61176992 endingPage "S130" @default.
- W61176992 startingPage "S130" @default.
- W61176992 abstract "Abstract The two-signal model of T cell activation has been focused on what costimulatory signals are necessary to facilitate and enhance T cell response to a specific antigen. However, it is also intriguing to study the ability for costimulatory interactions to induce signaling in the absence of specific antigen recognition. We examine the signaling of CD4+ T cells engaging high densities of CD80 molecules in the presence of ICAM-1 in an antigen-independent T cell response. Examination of freshly isolated naive mouse T cells interacting with CD80 and ICAM-1 reveals a novel role for CD28:CD80 interactions in antigen independent ring junction formation in which CD80:CD28 interactions were located in the central region. The unengaged T-cell receptor is also localized to this central region. These cells exhibit increased cytoplasmic Ca++ compared to cells interacting with ICAM-1 alone. With as many cells fluxing Calcium as seen in antigen dependent stimulation. Mouse T cells interacting with ICAM-1 and CD80 also show an increased level of phosphorylated tyrosine residues. Although there is signaling in an antigen independent T cell response, it is not sufficient for inducing IL-2 secretion. The higher expression levels of CD80 achieved in the bilayer distinguish these results from earlier studies (Bromley et al, 2001; Markiewicz et al 2005) showing no interaction of mouse CD28 and CD80 in the absence of antigen. Thus, CD28, as well as NKG2D (Somersalo et al, 2004; Markiewicz, 2005), can stimulation formation of antigen independent ring junctions. These experiments also demonstrate that CD4+ T cells can be induced to form antigen independent adhesion rings under conditions of high CD80 density. The function of these structures is under investigation. NIH AI44931" @default.
- W61176992 created "2016-06-24" @default.
- W61176992 creator A5015553967 @default.
- W61176992 creator A5041772105 @default.
- W61176992 date "2007-04-01" @default.
- W61176992 modified "2023-09-25" @default.
- W61176992 title "CD28:CD80 interactions mediate anitgen independent ring junction formation and signalling in T cells (87.15)" @default.
- W61176992 doi "https://doi.org/10.4049/jimmunol.178.supp.87.15" @default.
- W61176992 hasPublicationYear "2007" @default.
- W61176992 type Work @default.
- W61176992 sameAs 61176992 @default.
- W61176992 citedByCount "0" @default.
- W61176992 crossrefType "journal-article" @default.
- W61176992 hasAuthorship W61176992A5015553967 @default.
- W61176992 hasAuthorship W61176992A5041772105 @default.
- W61176992 hasConcept C147483822 @default.
- W61176992 hasConcept C148125776 @default.
- W61176992 hasConcept C154317977 @default.
- W61176992 hasConcept C185592680 @default.
- W61176992 hasConcept C19317047 @default.
- W61176992 hasConcept C202751555 @default.
- W61176992 hasConcept C203014093 @default.
- W61176992 hasConcept C2776090121 @default.
- W61176992 hasConcept C2778297628 @default.
- W61176992 hasConcept C39347974 @default.
- W61176992 hasConcept C55493867 @default.
- W61176992 hasConcept C67662055 @default.
- W61176992 hasConcept C86803240 @default.
- W61176992 hasConcept C8891405 @default.
- W61176992 hasConcept C95444343 @default.
- W61176992 hasConceptScore W61176992C147483822 @default.
- W61176992 hasConceptScore W61176992C148125776 @default.
- W61176992 hasConceptScore W61176992C154317977 @default.
- W61176992 hasConceptScore W61176992C185592680 @default.
- W61176992 hasConceptScore W61176992C19317047 @default.
- W61176992 hasConceptScore W61176992C202751555 @default.
- W61176992 hasConceptScore W61176992C203014093 @default.
- W61176992 hasConceptScore W61176992C2776090121 @default.
- W61176992 hasConceptScore W61176992C2778297628 @default.
- W61176992 hasConceptScore W61176992C39347974 @default.
- W61176992 hasConceptScore W61176992C55493867 @default.
- W61176992 hasConceptScore W61176992C67662055 @default.
- W61176992 hasConceptScore W61176992C86803240 @default.
- W61176992 hasConceptScore W61176992C8891405 @default.
- W61176992 hasConceptScore W61176992C95444343 @default.
- W61176992 hasIssue "1_Supplement" @default.
- W61176992 hasLocation W611769921 @default.
- W61176992 hasOpenAccess W61176992 @default.
- W61176992 hasPrimaryLocation W611769921 @default.
- W61176992 hasRelatedWork W1483285805 @default.
- W61176992 hasRelatedWork W1497854521 @default.
- W61176992 hasRelatedWork W1979841260 @default.
- W61176992 hasRelatedWork W2009108355 @default.
- W61176992 hasRelatedWork W2028926231 @default.
- W61176992 hasRelatedWork W2069335042 @default.
- W61176992 hasRelatedWork W2113315096 @default.
- W61176992 hasRelatedWork W2444226961 @default.
- W61176992 hasRelatedWork W320770476 @default.
- W61176992 hasRelatedWork W4313385038 @default.
- W61176992 hasVolume "178" @default.
- W61176992 isParatext "false" @default.
- W61176992 isRetracted "false" @default.
- W61176992 magId "61176992" @default.
- W61176992 workType "article" @default.