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• W61228008 abstract "Purines are the basic building blocks of many important molecules of vital physiologic significance. The most important purine molecule is adenosine 5’-triphosphate (ATP) in which 95% of chemical energy is stored and from which energy is derived to trigger numerous energy-dependent reactions. ATP is essential for generation of the second messenger cAMP and regulation of several ATP-sensitive enzymes, channels and myocardial contraction-relaxation coupling. ATP is crucial in maintaining ionic gradients, neurotransmitter release, nerve depolarization and conduction, gene expression and nucleic and deoxynucleic acid synthesis (RNA and DNA) during myocardial development and cardiac repair. ATP and derivatives (ADP, AMP, adenosine and cAMP) are crucial for several molecular cellular events responsible for and regulation of vascular tone and contractile activity in the heart. In addition to purines, other nucleotides and nucleosides also play a significant role cellular and molecular biology. In the heart, the most abundant purine derivative is ATP and about 95% of ATP is synthesized in the mitochondria. In normal physiologic conditions, the steady state level of myocardial ATP is in a critical balance between ATP production and utilization. Mitochondrial adenine nucleotide translocase transfers ATP from the mitochondria to the cytosol in exchange for ADP." @default.
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• W61228008 date "1996-01-01" @default.
• W61228008 modified "2023-09-26" @default.
• W61228008 title "Physiologic and Pathophysiologic Significance of Purine Metabolism in the Heart" @default.
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• W61228008 doi "https://doi.org/10.1007/978-1-4613-0455-5_1" @default.
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