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- W61292364 abstract "Sulfonylurea receptor-2 is a subunit of ATP-sensitive K-channels (KATP) that have been implicated in protecting hearts from ischemia reperfusion (I/R) injury. Surprisingly, SUR2 knockout (SUR2KO) male mice are protected against I/R injury. A 55kDa intra-exonic splice variant of SUR2A (SUR2A-55) unique to mitochondrial membrane fractions forms functional KATP channels and is more abundant in mitochondria of SUR2KO mice than in wild type (Wt). We hypothesized that increased expression of SUR2A-55 protects hearts from I/R injury. We established three transgenic (Tg+) mouse lines with 1, 3 or >5 copies of the SUR2A-55 transgene using a cardiac specific α-MHC promoter in the Wt background. Cardiac specific mitochondrial expression of SUR2A-55 increased in the order Wt < Tg+1 < Tg+3 < Tg+5 by immunoblotting and RT-PCR. Survival of the Tg+5 mice was low presumably due to toxic over-expression. After 30 min ischemia and 24 h reperfusion, the infarct sizes in Tg+1 (10±3%, n=11, p<0.05) and Tg+3 (7±3%, n=9, p<0.001..." @default.
- W61292364 created "2016-06-24" @default.
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- W61292364 date "2010-11-23" @default.
- W61292364 modified "2023-09-26" @default.
- W61292364 title "Abstract 15914: Mitochondrial Short Form Sulfonylurea Receptors-2A Splice Variant Protects Hearts From Ischemia Reperfusion Injury." @default.
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