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- W613149512 abstract "ASK 2/MAPKKK 6 was identified as a member of the MAPKKK family, which shares 45% amino acid identity with ASK 1/MAPKKK 5. In this study, the genomic organization and promoter of mouse ASK 2 were determined. ASK 2 gene spans approximately 12 kb and is comprised of 29 exons, flanked by 5' regulatory regions. Through comparison with ASK 2 cDNA variant clones, two splice variants were identified: a transcript lacking 24 bases encoding 8 amino acids was caused by disuse of exon 3, and another frameshifted transcript due to 4 bases deletion was produced by usage of the first 4 bases of exon 17 as a part of the splicing acceptor. Reporter plasmid analysis demonstrated that a promoter existed in the immediate upstream region adjacent to exon 1. Interestingly, the 5'-flanking region of the promoter possessed a strong suppressive element. These results suggest that expression of ASK 2 is regulated by multiple mechanisms." @default.
- W613149512 created "2016-06-24" @default.
- W613149512 creator A5090667417 @default.
- W613149512 date "2003-01-01" @default.
- W613149512 modified "2023-10-18" @default.
- W613149512 title "Genomic Organization and Promoter Analysis of Mouse Apoptosis Signal-regulating Kinase 2 (ASK2)" @default.
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- W613149512 doi "https://doi.org/10.5357/koubyou.70.9" @default.
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