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- W61354974 abstract "ABSTRACT The presence of benzyl cyanide in the volatile constituents of Juncus roemerianus prompted us to initiate analyses of alkaloids in three species of vascular plants that are most abundant in the tidal marshes of Mississippi. An unexpected high amount (2.0 g/kg) of total alkaloidal fraction was found in the adult needlerush Juncus roemerianus and as much as 1.5 g/kg in the giantcordgrass Spartina cynosuroides, and the bulrush Scirpus americanus. Subsequent analysis of the volatile constituents of S. cynosuroides by combined GLC-MS revealed indole among 60 compounds which we could identify. The presence of benzyl cyanide and indole in the volatile constituents of these plants also pointed toward the possible presence of indole alkaloids. Since two of the most potent anti-leukemic agents, VLB and vincristine, are dimeric indole alkaloids, these observations led us to submit crude extracts from these plants to the National Cancer Institute for screening of their possible antitumor activity. Extracts of seventeen species of marsh plants have been screened against P 388 lymphocytic leukemia in BDF 1 mice. These tests have resulted in the detection of significant activity in some twelve species of marsh plants. Further examination of the extract of Juncus roemerianus has resulted in the isolation of the new tumor inhibitor, juncusol. Antitumor agents are currently being isolated from the other marsh plants which have demonstrated significant activity." @default.
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- W61354974 date "1976-01-01" @default.
- W61354974 modified "2023-09-27" @default.
- W61354974 title "PHARMACOLOGICAL POTENTIAL OF MARSH PLANTS" @default.
- W61354974 cites W1977869659 @default.
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- W61354974 doi "https://doi.org/10.1016/b978-0-12-751801-5.50030-7" @default.
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