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- W613915219 abstract "Improvements in specimen preparation techniques and instrumentation have made it possible to perform high-resolution electron microscope and electron diffraction studies of biological systems under conditions approaching the hydrated native state. As a result of the better morphological and histochemical preservation achieved by these techniques, including liquid-helium cryofixation and related low-temperature methods, previously undetected unit components have been observed in the plane of the layers of photo-receptors and related lamellar systems. Correlated electron-microscope and biochemical studies of mitochondrial membranes have resulted in the detection and isolation of a fundamental unit of energy transduction, corresponding to the respiratory enzyme assemblies in mitochondrial membranes. Enhanced contrast and resolution of the order of 8Å were achieved in direct studies of the macromolecular organization of τ2 bacteriophage particles, ribosomes, and of isolated cell constituents. Electron microbeam probes, measuring only 100 to 1,000 Å in diameter, have also been applied in controlled irradiation of selected minute regions of hydrated systems containing DNA, including the head portion of single bacteriophage particles and viable bacterial spores." @default.
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- W613915219 date "1962-01-01" @default.
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- W613915219 title "NEW APPROACHES IN THE STUDY OF BIOLOGICAL ULTRASTRUCTURE BY HIGH-RESOLUTION ELECTRON MICROSCOPY" @default.
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- W613915219 doi "https://doi.org/10.1016/b978-1-4832-3079-5.50026-6" @default.
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