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- W61392997 abstract "Toxoplasma gondii infects a wide range of warm-blooded vertebrates including humans and is one of the world’s most successful parasites. As a member of the phylum Apicomplexa, T. gondii is a model for understanding infection by a variety of related parasites such as Plasmodium and Cryptosporidium. Apicomplexans use a unique form of actin-based motility to directly penetrate their host cell, without the need for host uptake mechanisms. Invasion occurs more rapidly than phagocytic uptake and avoids triggering of the respiratory burst in macrophages. Within the host cell, the parasite resides in a modified vacuole that resists fusion with endosomes and lysosomes, while intimately associate with host cell ER and mitochondria. Active secretion of parasite proteins results in modification of the vacuole, rendering it permeable to small molecules. Within this porous vacuole the parasite acquires nutrients from the host cytosol, allowing rapid replication, and eventual consumption of the host cell prior to egress. Understanding the complex biology of intracellular survival by T. gondii has bearing on the mechanisms of host resistance during both acute and chronic infection." @default.
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- W61392997 date "2007-06-21" @default.
- W61392997 modified "2023-09-26" @default.
- W61392997 title "Invasion and Intracellular Survival by Toxoplasma" @default.
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- W61392997 doi "https://doi.org/10.1201/9781498713047-6" @default.
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