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- W614106894 abstract "Halitosis (oral malodour) while not a classic disease is prevalent and can besocially disabling; thus studying the origins and control of malodour are sociallyand commercially important. Volatile sulfur compounds (VSCs) are importantcontributors to halitosis, and can be combated by adding zinc to oral careproducts. The aims of the thesis were to develop a model system to grow mixedculture, tongue-derived microbial biofilms in vitro. This model was used toinvestigate the efficacy of zinc as a VSC-reducing and antimicrobial agent, aswell as visualising the distribution and retention of zinc within the biofilms.A perfusion biofilm model (PBM) was established with sorbarod filters as amicrocosm representing the tongue. Treatments with zinc toothpaste, placebotoothpaste, zinc sulfate solution (ZnSO4) and deionised water were assessedusing a portable gas chromatograph (OralChromaT'V'), microbiological assays,confocal microscopy and inductively coupled plasma-mass spectrometry (lCP-MS). Zinc significantly reduced hydrogen sulfide concentrations but had amoderate effect on methanethiol. The zinc and placebo toothpaste exhibitedbacteriostatic effects, confirmed by plate counting and confocal live-deadimages. Zinc was retained and visible to a greater extent in the zinc toothpastetreated biofilm compared to ZnSO4 solution; distribution varied markedlybetween biofilm layers and replicates. lCP-MS confirmed presence of zinc.PBM was shown to be a suitable model for studying sources of oral malodour.Zinc reduced VSCs, probably by binding sulfur compounds forming insolublezinc sulfides; zinc had a bacteriostatic effect, potentially due to metabolicinhibition, which was increased by other toothpaste ingredients. The varieddistribution of zinc reflected the heterogeneity and complexity in the architecture of mature biofilms. In conclusion, zinc had multifactorial effects on VSCs,including antimicrobial and VSC reducing. Retention of zinc was visible,however with variations in distribution within the biofilms. Further work isneeded; including conducting human microbe identification microarrays." @default.
- W614106894 created "2016-06-24" @default.
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- W614106894 date "2014-04-01" @default.
- W614106894 modified "2023-09-23" @default.
- W614106894 title "Development and applications of models of oral maladour" @default.
- W614106894 hasPublicationYear "2014" @default.
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