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• W61416099 abstract "Efficient DNA replication is a process absolutely required for all forms of life. An essential component of the replisome, known as the sliding clamp, is a toroidal-shaped complex that encircles DNA and serves to tether the DNA polymerase to the template DNA strand. Although they were initially discovered as DNA polymerase processivity factors, sliding clamps are used by many enzymes required for DNA replication and repair. Sliding clamps have been identified and characterized in all domains of life from prokaryotes to eukaryotes. Although the amino acid sequence and architecture of these clamps differ within and between species, they all share some basic physical properties and mechanisms of action. Thus, the sliding clamp seems to have evolved as an efficient mechanism for ensuring proficient DNA replication." @default.
• W61416099 created "2016-06-24" @default.
• W61416099 creator A5002499771 @default.
• W61416099 creator A5027447638 @default.
• W61416099 date "2013-01-01" @default.
• W61416099 modified "2023-09-24" @default.
• W61416099 title "Sliding Clamps in DNA Replication: Escherichia coli β-Clamp and PCNA Structure" @default.
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• W61416099 doi "https://doi.org/10.1016/b978-0-12-378630-2.00442-4" @default.
• W61416099 hasPublicationYear "2013" @default.
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