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- W614500920 abstract "317 Objectives Although PET/CT has been considered as an efficient tool for pathologic tumor response prediction after neoadjuvant CRT in locally advanced rectal cancer (LARC), discrimination between residual tumor and inflammation after therapy still remains as the major pitfalls. This study is aimed to evaluate response more accurately by adding a delayed phase imaging to the conventional PET/CT protocol. Methods 61 LARC patients were enrolled and treated with neoadjuvant CRT. PET/CT was performed before and after neoadjuvant CRT and protocol is composed of early (60 min) and delayed phase (90 min) imaging. Percent SUVmax reduction (Response Index, RI) of early phase (RI-early = [(Pre-CRT 60 min SUVmax)-(Post-CRT 60 min SUVmax)] / (Pre-CRT 60 min SUVmax)×100) and delayed phase (RI-delay = [(Pre-CRT 90 min SUVmax)-(Post-CRT 90 min SUVmax)] / (Pre-CRT 90 min SUVmax)×100) were considered. And we defined new parameter has not ever been used, Delay Index (DI = [(Post-CRT 90 min SUVmax)-(Post-CRT 60 min SUVmax)] / (Post-CRT 90 min SUVmax)). These parameters were compared with the Dworak tumor regression grade (TRG) as a gold standard after surgery. Results 15 patients were responders with total or near total regression (TRG3-4), whereas 41 patients with TRG1-2 were non-responders. Between responders and non-responders, all of RI-early, RI-delay and DI indices showed significant differences (RI-early; 88% vs. 56%, p Conclusions In this study, all of RI-early, RI-delay and DI were efficient to predict pathologic response after neoadjuvant CRT. Among those parameters, RI-delay and DI showed higher specificity than conventional RI-early. Especially, delay index showed the highest specificity without sacrificing sensitivity" @default.
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- W614500920 date "2011-05-01" @default.
- W614500920 modified "2023-09-25" @default.
- W614500920 title "Neoadjuvant chemoradiation therapy response evaluation using dual time point PET/CT in rectal cancer" @default.
- W614500920 hasPublicationYear "2011" @default.
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