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- W61475327 abstract "Publisher Summary This chapter describes the different aspects of nerve growth factor (NGF). The finding that administration of NGF-antiserum to newborn animals leads to an extensive destruction of the peripheral sympathetic nervous system opened up a new facet of the biological function of NGF and provided neurobiologists and neuropharmacologists with an extremely useful tool for which the term immunosympathectomy was coined. It is found that when immunosympathectomy was supplemented, and to some extent challenged, by chemical sympathectomy using 6-hydroxydopamine nobody suspected that also the mechanism of chemical sympathectomy could be linked to the action of NGF. Experiments have provided evidence that chemical sympathectomy in newborn animals is affected by 6-hydroxydopamine most probably represents nothing more than an interruption of the natural supply of NGF by destroying the adrenergic nerve terminals by which NGF is taken up, and transported retrogradely to the cell body. This assumption was supported by the observations that not only destruction of the adrenergic nerve terminals of newborn animals by 6-hydroxydopamine, but also surgical axotomy leads to an irreversible damage and finally death of the adrenergic cell bodies." @default.
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- W61475327 date "1976-01-01" @default.
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- W61475327 title "CHAIRMAN'S INTRODUCTION TO THE SYMPOSIUM ON “NERVE GROWTH FACTOR”" @default.
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- W61475327 doi "https://doi.org/10.1016/b978-0-08-020540-3.50026-3" @default.
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