Matches in SemOpenAlex for { <https://semopenalex.org/work/W6149997> ?p ?o ?g. }
- W6149997 abstract "The role of natural-killer (NK) cells in the treatment of hematological malignancies has been investigated intensively during the past three decades. Until recently, the majority of research has focused on the use of in vitro or in vivo cytokine-expanded and -activated NK cells against autologous cancer cells, with generally disappointing results. The lack of observed efficacy of past attempts to harness the antitumor effect of NK cells can now be explained largely by inhibitory interactions between major histocompatibility complex class I molecules expressed on tumor cells and inhibitory receptors on NK cells. Better appreciation of how NK cells selectively recognize and kill target cells while sparing normal cells is evolving. Major families of cell surface receptors that inhibit and activate NK cells to lyse target cells have been characterized, including killer cell immunoglobulin-like receptors, C-type lectins, and natural cytotoxicity receptors. In addition, identification of NK cell receptor ligands and their expression on normal and transformed cells is becoming better elucidated. The improved understanding of NK cell receptor biology has paved the way for development of novel and rational clinical approaches to manipulating receptor-ligand interactions for immunotherapy." @default.
- W6149997 created "2016-06-24" @default.
- W6149997 creator A5049192022 @default.
- W6149997 creator A5056697792 @default.
- W6149997 date "2006-01-01" @default.
- W6149997 modified "2023-10-05" @default.
- W6149997 title "The Therapeutic Use of Natural-Killer Cells in Hematological Malignancies" @default.
- W6149997 cites W105759314 @default.
- W6149997 cites W114762935 @default.
- W6149997 cites W1274344746 @default.
- W6149997 cites W133892101 @default.
- W6149997 cites W1506621673 @default.
- W6149997 cites W1508132320 @default.
- W6149997 cites W1527454180 @default.
- W6149997 cites W1532737852 @default.
- W6149997 cites W1538843350 @default.
- W6149997 cites W1556867369 @default.
- W6149997 cites W1574784499 @default.
- W6149997 cites W1583511232 @default.
- W6149997 cites W1634636209 @default.
- W6149997 cites W1748948219 @default.
- W6149997 cites W1828347693 @default.
- W6149997 cites W1861839200 @default.
- W6149997 cites W186390619 @default.
- W6149997 cites W1879871130 @default.
- W6149997 cites W1944965129 @default.
- W6149997 cites W1961068945 @default.
- W6149997 cites W1967558681 @default.
- W6149997 cites W1969814796 @default.
- W6149997 cites W1970563382 @default.
- W6149997 cites W1971596521 @default.
- W6149997 cites W1971712854 @default.
- W6149997 cites W1973246346 @default.
- W6149997 cites W1977445553 @default.
- W6149997 cites W1979386953 @default.
- W6149997 cites W1980036435 @default.
- W6149997 cites W1985424578 @default.
- W6149997 cites W1991992194 @default.
- W6149997 cites W1994232628 @default.
- W6149997 cites W1998259116 @default.
- W6149997 cites W1999474577 @default.
- W6149997 cites W1999839845 @default.
- W6149997 cites W2000304823 @default.
- W6149997 cites W2002647828 @default.
- W6149997 cites W2005426453 @default.
- W6149997 cites W2006073656 @default.
- W6149997 cites W2008992933 @default.
- W6149997 cites W2011330570 @default.
- W6149997 cites W2013283636 @default.
- W6149997 cites W2016200146 @default.
- W6149997 cites W2019364572 @default.
- W6149997 cites W2020181553 @default.
- W6149997 cites W2020846586 @default.
- W6149997 cites W2023144585 @default.
- W6149997 cites W2026832758 @default.
- W6149997 cites W2027315624 @default.
- W6149997 cites W2029667797 @default.
- W6149997 cites W2038260086 @default.
- W6149997 cites W2040618321 @default.
- W6149997 cites W2044311624 @default.
- W6149997 cites W2044360617 @default.
- W6149997 cites W2044833002 @default.
- W6149997 cites W2047819151 @default.
- W6149997 cites W2052502668 @default.
- W6149997 cites W2054150065 @default.
- W6149997 cites W2056031584 @default.
- W6149997 cites W2057962059 @default.
- W6149997 cites W2058522060 @default.
- W6149997 cites W2059467769 @default.
- W6149997 cites W2062581776 @default.
- W6149997 cites W2063157305 @default.
- W6149997 cites W2063418940 @default.
- W6149997 cites W2065913200 @default.
- W6149997 cites W2067564880 @default.
- W6149997 cites W2068660216 @default.
- W6149997 cites W2068923616 @default.
- W6149997 cites W2070091724 @default.
- W6149997 cites W2075293216 @default.
- W6149997 cites W2080518419 @default.
- W6149997 cites W2083786790 @default.
- W6149997 cites W2087558696 @default.
- W6149997 cites W2095636772 @default.
- W6149997 cites W2101283545 @default.
- W6149997 cites W2104066024 @default.
- W6149997 cites W2116171543 @default.
- W6149997 cites W2122887099 @default.
- W6149997 cites W2128402413 @default.
- W6149997 cites W2130649175 @default.
- W6149997 cites W2132268212 @default.
- W6149997 cites W2132363654 @default.
- W6149997 cites W2133184513 @default.
- W6149997 cites W2134829737 @default.
- W6149997 cites W2144891041 @default.
- W6149997 cites W2147068163 @default.
- W6149997 cites W2154518608 @default.
- W6149997 cites W2155690142 @default.
- W6149997 cites W2157972657 @default.
- W6149997 cites W2161122282 @default.
- W6149997 cites W2164296311 @default.
- W6149997 cites W2164753292 @default.