Matches in SemOpenAlex for { <https://semopenalex.org/work/W61578701> ?p ?o ?g. }
- W61578701 endingPage "84" @default.
- W61578701 startingPage "61" @default.
- W61578701 abstract "This review aims at discussing the molecular details of binding specificity, promiscuity and mechanisms of phosphopeptide recognition to modular domains using computational tools. Protein–phosphoprotein interactions are the driving forces that underline multiple signalling events which are important in cellular function. Understanding protein–phosphopeptide recognition assists designing phosphopeptide sequences as inhibitors to manipulate protein–protein interactions for cell biology studies and therapeutics. Notably, the modular domain–phosphopeptide binding is mostly promiscuous and weak binding, which significantly differs from most protein–ligand binding systems used for drug design. In this chapter, we review recent advances in computational work for modular domain–phosphopeptide binding and knowledge gained for their binding mechanisms. We discuss the phosphopeptide binding of modular domains in DNA damage responses, FHA and BRCT, the smallest modular domain WW and the tyrosine kinase binding domain, such as Cbl–TKB that recognizes phosphotyrosine. We also discuss challenges and possible future directions for improving peptide design as inhibitors for phosphoprotein–protein binding." @default.
- W61578701 created "2016-06-24" @default.
- W61578701 creator A5010396882 @default.
- W61578701 creator A5032380209 @default.
- W61578701 date "2013-01-01" @default.
- W61578701 modified "2023-09-23" @default.
- W61578701 title "Atomistic Modelling of Phosphopeptide Recognition for Modular Domains" @default.
- W61578701 cites W1512133948 @default.
- W61578701 cites W1607931568 @default.
- W61578701 cites W1617092022 @default.
- W61578701 cites W1624856187 @default.
- W61578701 cites W1934253652 @default.
- W61578701 cites W1970103851 @default.
- W61578701 cites W1971040573 @default.
- W61578701 cites W1971696898 @default.
- W61578701 cites W1973489939 @default.
- W61578701 cites W1975979524 @default.
- W61578701 cites W1977856948 @default.
- W61578701 cites W1982499456 @default.
- W61578701 cites W1984347834 @default.
- W61578701 cites W1985767604 @default.
- W61578701 cites W1987153424 @default.
- W61578701 cites W1988805210 @default.
- W61578701 cites W1992898397 @default.
- W61578701 cites W1992899488 @default.
- W61578701 cites W1995110951 @default.
- W61578701 cites W1995141374 @default.
- W61578701 cites W1997034002 @default.
- W61578701 cites W2003589493 @default.
- W61578701 cites W2004299515 @default.
- W61578701 cites W2010004274 @default.
- W61578701 cites W2010255232 @default.
- W61578701 cites W2011516085 @default.
- W61578701 cites W2013180816 @default.
- W61578701 cites W2013650805 @default.
- W61578701 cites W2015778367 @default.
- W61578701 cites W2018783142 @default.
- W61578701 cites W2019727578 @default.
- W61578701 cites W2022473533 @default.
- W61578701 cites W2023739089 @default.
- W61578701 cites W2029616605 @default.
- W61578701 cites W2031034846 @default.
- W61578701 cites W2032126507 @default.
- W61578701 cites W2034098267 @default.
- W61578701 cites W2036239645 @default.
- W61578701 cites W2043816461 @default.
- W61578701 cites W2050159278 @default.
- W61578701 cites W2051381895 @default.
- W61578701 cites W2052292155 @default.
- W61578701 cites W2052983166 @default.
- W61578701 cites W2054739661 @default.
- W61578701 cites W2060770087 @default.
- W61578701 cites W2062231783 @default.
- W61578701 cites W2064047482 @default.
- W61578701 cites W2064761203 @default.
- W61578701 cites W2065148800 @default.
- W61578701 cites W2065306175 @default.
- W61578701 cites W2068176376 @default.
- W61578701 cites W2070753604 @default.
- W61578701 cites W2078818508 @default.
- W61578701 cites W2084295374 @default.
- W61578701 cites W2086687548 @default.
- W61578701 cites W2093221728 @default.
- W61578701 cites W2094144878 @default.
- W61578701 cites W2094401284 @default.
- W61578701 cites W2095559419 @default.
- W61578701 cites W2095773792 @default.
- W61578701 cites W2097412382 @default.
- W61578701 cites W2103723321 @default.
- W61578701 cites W2104293639 @default.
- W61578701 cites W2105406875 @default.
- W61578701 cites W2116682661 @default.
- W61578701 cites W2118200955 @default.
- W61578701 cites W2119267663 @default.
- W61578701 cites W2120172924 @default.
- W61578701 cites W2121520117 @default.
- W61578701 cites W2122650097 @default.
- W61578701 cites W2127469284 @default.
- W61578701 cites W2129386377 @default.
- W61578701 cites W2130797528 @default.
- W61578701 cites W2131036059 @default.
- W61578701 cites W2134253380 @default.
- W61578701 cites W2140797130 @default.
- W61578701 cites W2141885858 @default.
- W61578701 cites W2142095264 @default.
- W61578701 cites W2142868265 @default.
- W61578701 cites W2144288821 @default.
- W61578701 cites W2144829210 @default.
- W61578701 cites W2145029005 @default.
- W61578701 cites W2145080853 @default.
- W61578701 cites W2146387970 @default.
- W61578701 cites W2148425143 @default.
- W61578701 cites W2152301430 @default.
- W61578701 cites W2152808422 @default.
- W61578701 cites W2155165405 @default.
- W61578701 cites W2156558844 @default.
- W61578701 cites W2160406438 @default.
- W61578701 cites W2161460305 @default.