Matches in SemOpenAlex for { <https://semopenalex.org/work/W6160963> ?p ?o ?g. }
- W6160963 endingPage "550" @default.
- W6160963 startingPage "495" @default.
- W6160963 abstract "Vaccination is one of the most useful scientific developments in the control and eradication of human disease. Early vaccines were based on whole organism preparations which, although efficacious in some cases (smallpox), had disadvantages which severely limited their general use. Because of the complexity of bacteria, it is difficult to maintain consistency of potency in terms of immunological protection, and, more importantly, to avoid severe toxic or other deleterious effects caused by indigenous component molecules (lipopolysaccharide or peptidoglycan) of some pathogenic bacteria. The discoveries of a “specific soluble substance” secreted by Pneumococci during growth1 and the immunogenicity of these substances (capsular polysaccharides)2 were new and important developments in vaccine technology. It was demonstrated3 that this substance was in fact a type-specific polysaccharide that was able to quantitatively precipitate4 antibodies produced in animals by injection of the homologous, whole organisms. In subsequent pioneering work5 it was demonstrated that when used as human vaccines these purified polysaccharides provide type-specific protection against the development of pneumococcal infection. However, at this critical stage of development the phenomenal success of antibiotic therapy for treating bacterial infections overshadowed the early promise of polysaccharide vaccines." @default.
- W6160963 created "2016-06-24" @default.
- W6160963 creator A5031462808 @default.
- W6160963 date "1988-01-01" @default.
- W6160963 modified "2023-09-25" @default.
- W6160963 title "Chemically Modified Capsular Polysaccharides as Vaccines" @default.
- W6160963 cites W1483463638 @default.
- W6160963 cites W1505126644 @default.
- W6160963 cites W1532606334 @default.
- W6160963 cites W1534550817 @default.
- W6160963 cites W1539737337 @default.
- W6160963 cites W1566010497 @default.
- W6160963 cites W1568082126 @default.
- W6160963 cites W1575329439 @default.
- W6160963 cites W1592020071 @default.
- W6160963 cites W1632209234 @default.
- W6160963 cites W1807470715 @default.
- W6160963 cites W1808949860 @default.
- W6160963 cites W1883559086 @default.
- W6160963 cites W1885106571 @default.
- W6160963 cites W1907165492 @default.
- W6160963 cites W1963696702 @default.
- W6160963 cites W1967541644 @default.
- W6160963 cites W1970276449 @default.
- W6160963 cites W1973815343 @default.
- W6160963 cites W1977007850 @default.
- W6160963 cites W1977370563 @default.
- W6160963 cites W1981040794 @default.
- W6160963 cites W1989844289 @default.
- W6160963 cites W1991844560 @default.
- W6160963 cites W1992922470 @default.
- W6160963 cites W1999047723 @default.
- W6160963 cites W2000491724 @default.
- W6160963 cites W2001637853 @default.
- W6160963 cites W2003601779 @default.
- W6160963 cites W2004672606 @default.
- W6160963 cites W2005421617 @default.
- W6160963 cites W2009274562 @default.
- W6160963 cites W2010289320 @default.
- W6160963 cites W2010394095 @default.
- W6160963 cites W2011341850 @default.
- W6160963 cites W2014516062 @default.
- W6160963 cites W2020723576 @default.
- W6160963 cites W2022530133 @default.
- W6160963 cites W2023973164 @default.
- W6160963 cites W2030513162 @default.
- W6160963 cites W2030785840 @default.
- W6160963 cites W2047258440 @default.
- W6160963 cites W2053163557 @default.
- W6160963 cites W2053564530 @default.
- W6160963 cites W2053875923 @default.
- W6160963 cites W2054495382 @default.
- W6160963 cites W2058201960 @default.
- W6160963 cites W2059296531 @default.
- W6160963 cites W2059579071 @default.
- W6160963 cites W2091862122 @default.
- W6160963 cites W2094437035 @default.
- W6160963 cites W2106665982 @default.
- W6160963 cites W2117542724 @default.
- W6160963 cites W2118575726 @default.
- W6160963 cites W2130036682 @default.
- W6160963 cites W2133713208 @default.
- W6160963 cites W2134243733 @default.
- W6160963 cites W2140288745 @default.
- W6160963 cites W2146275508 @default.
- W6160963 cites W2158281511 @default.
- W6160963 cites W2160484471 @default.
- W6160963 cites W2160650519 @default.
- W6160963 cites W2162242806 @default.
- W6160963 cites W2169253475 @default.
- W6160963 cites W2250068495 @default.
- W6160963 cites W2330258760 @default.
- W6160963 cites W2615970075 @default.
- W6160963 cites W2620946873 @default.
- W6160963 cites W4248258351 @default.
- W6160963 doi "https://doi.org/10.1007/978-1-4613-1663-3_18" @default.
- W6160963 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/2459932" @default.
- W6160963 hasPublicationYear "1988" @default.
- W6160963 type Work @default.
- W6160963 sameAs 6160963 @default.
- W6160963 citedByCount "19" @default.
- W6160963 countsByYear W61609632013 @default.
- W6160963 countsByYear W61609632014 @default.
- W6160963 countsByYear W61609632015 @default.
- W6160963 countsByYear W61609632016 @default.
- W6160963 crossrefType "book-chapter" @default.
- W6160963 hasAuthorship W6160963A5031462808 @default.
- W6160963 hasConcept C100817775 @default.
- W6160963 hasConcept C159654299 @default.
- W6160963 hasConcept C203014093 @default.
- W6160963 hasConcept C22070199 @default.
- W6160963 hasConcept C2776634448 @default.
- W6160963 hasConcept C2780868878 @default.
- W6160963 hasConcept C2781253189 @default.
- W6160963 hasConcept C501593827 @default.
- W6160963 hasConcept C523546767 @default.
- W6160963 hasConcept C54355233 @default.
- W6160963 hasConcept C55493867 @default.