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- W616864080 abstract "Microcantilevers have now been used successfully for over a decade. New assays are being developed and tested continuously but the technique has not arrived inhospitals and surgeries yet. The main obstacle was that a robust and reliable readout system which does not need intricate alignment before each measurement was notavailable. Therefore cantilever devices have only been used in university laboratories.The aim of the research presented in this thesis is to provide a diffractive optical readout for cantilever bending that is rapid, robust and easy to use.The diffractive readout discovered during my PhD involves a laser illuminating the entire cantilever and additionally parts of the chip base to which it is attached.The laser light diffracted from the cantilever contains information that allows a distinction to be made between tilting and bending of the cantilever. Additionally,measurements of the absolute tilting and bending can be performed and the timeneeded for aligning the cantilever chip in the laser beam is reduced to a minimum.This thesis describes the tools used to develop the diffractive readout and presentsexperimental results. First, a simulation was programmed to predict resultsand optimise experimental conditions. Second, an experimental setup was built fromscratch and a new ow cell designed which was needed for transmission mode experiments.Third, test experiments in air were performed using a transmissive and areflective diffraction approach. Fourth and finally, the applicability of the diffractive readout was shown by demonstrating that the binding of the antibiotic vancomycinto a glycopeptide could be measured successfully.I hope that the invention presented in this thesis will help to commercialise the cantilever setup and make it attractive for the use in hospital and surgeries speedingup diagnostic steps from days down to a few minutes.This thesis lays the cornerstone of the discovered, patented and tested opticaldiffractive readout technique for cantilever based biosensors. Optimisation of theexperiment, being very important and essential, has to be focused on in the futureand is not dealt with in detail in here." @default.
- W616864080 created "2016-06-24" @default.
- W616864080 creator A5003573083 @default.
- W616864080 date "2010-06-28" @default.
- W616864080 modified "2023-09-26" @default.
- W616864080 title "Robust optical diffractive technique to read out cantilever deflection" @default.
- W616864080 hasPublicationYear "2010" @default.
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