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- W617633337 abstract "Eight new cafestol-type diterpenoids, tricalysins A-H (1-8), along with five known analogues (9-13), were isolated from the twigs of Tricalysia fruticosa. The structures of 1-8 were elucidated by the application of spectroscopic methods. Inhibitory effects of the isolates on nitric oxide (NO) production in lipopolysaccaride-activated RAW 264.7 macrophages were evaluated, and compound 8 exhibited the most potent bioactivity, with an IC50 value of 6.6 ± 0.4 μM. It was shown further that compound 8 inhibits inflammatory responses via suppression of the expression of iNOS and reduction of the production of the pro-inflammatory cytokines IL-6 and TNF-α, resulting from activation of nuclear factor-kappaB (NF-κB) and phosphorylation of MAPKs (ERK, JNK, and p38)." @default.
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- W617633337 date "2015-06-08" @default.
- W617633337 modified "2023-10-18" @default.
- W617633337 title "Cafestol-Type Diterpenoids from the Twigs of <i>Tricalysia fruticosa</i> with Potential Anti-inflammatory Activity" @default.
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- W617633337 doi "https://doi.org/10.1021/acs.jnatprod.5b00165" @default.
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