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- W618067072 abstract "Butyratre, short chain fatty acid (SCFA) increases intestinal adaptation but the association with SCFA receptors and transporters in intestinal failure (IF) is unknown. We hypothesized that prebiotic supplementation would increase butyrate, FFAR2, FFAR3, MCT1 and SMCT1 mRNA in an IF piglet model. Neonatal piglets (n=87) underwent an 80% jejunoileal resection and placement of a jugular catheter. Piglets received 80% parenteral and 20% enteral nutrition (EN) for 1, 3 or 7 days (d). Control (con) received unsupplemented EN, prebiotic (pre) 10 g/L EN short chain fructooligosaccharides (scFOS), probiotic (pro) 1×109 CFU LGG, and synbiotic (syn) received scFOS + LGG. SCFA, ileum and colon mRNA were analyzed as a randomized block design and considered significant at p≤0.05. Pre increased butyrate vs. con independent of time (p=0.05), while other SCFA did not differ. Ileal FFAR2 and FFAR3 mRNA were greatest in the pre and pro group vs. con on d1 (p=0.01 and 0.01). By d7, pro was greater than pre and syn but similar to con for FFAR2 and FFAR3 (p=0.03 and <0.01). Ileal MCT1 and SMCT1 mRNA increased in all groups vs. con on d1 (p=0.01 and 0.01). On d7, ileal MCT1 mRNA was greater in all groups vs. syn (p<0.01). Colon mRNA levels were not significantly impacted by treatment. This study shows that scFOS increases butyrate in a pediatric IF model, but that SCFA receptor and transporter mRNA levels are influenced by other factors. Grant Funding Source: NIH Ruth L. Kirschstein Institutional National Research Service Award 5T32 DK59802" @default.
- W618067072 created "2016-06-24" @default.
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- W618067072 date "2013-04-01" @default.
- W618067072 modified "2023-09-23" @default.
- W618067072 title "Prebiotic short chain fructooligosaccharides increase butyrate but not short chain fatty acid receptor or transporter mRNA in an intestinal failure piglet model" @default.
- W618067072 doi "https://doi.org/10.1096/fasebj.27.1_supplement.867.6" @default.
- W618067072 hasPublicationYear "2013" @default.
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