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- W618374626 startingPage "737" @default.
- W618374626 abstract "The aims of the current study were to prepare chitosan nanoparticles (CNPs) and to evaluate its protective role alone or in combination with quercetin (Q) against AFB1-induce cytotoxicity in rats. Male Sprague-Dawley rats were divided into 12 groups and treated orally for 4 weeks as follow: the control group, the group treated with AFB1 (80 μg/kg b.w.) in corn oil, the groups treated with low (140 mg/kg b.w.) or high (280 mg/kg b.w.) dose of CNPs, the group treated with Q (50 mg/kg b.w.), the groups treated with Q plus the low or the high dose of CNPs and the groups treated with AFB1 plus Q and/or CNPs at the two tested doses. The results also revealed that administration of AFB1 resulted in a significant increase in serum cytokines, Procollagen III, Nitric Oxide, lipid peroxidation and DNA fragmentation accompanied with a significant decrease in GPx I and Cu–Zn SOD-mRNA gene expression. Q and/or CNPs at the two tested doses overcome these effects especially in the group treated with the high dose of CNPs plus Q. It could be concluded that CNPs is a promise candidate as drug delivery enhances the protective effect of Q against the cytogenetic effects of AFB1 in high endemic areas." @default.
- W618374626 created "2016-06-24" @default.
- W618374626 creator A5012522678 @default.
- W618374626 creator A5013868465 @default.
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- W618374626 creator A5087148837 @default.
- W618374626 date "2015-01-01" @default.
- W618374626 modified "2023-10-10" @default.
- W618374626 title "Chitosan nanoparticles and quercetin modulate gene expression and prevent the genotoxicity of aflatoxin B 1 in rat liver" @default.
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