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- W61853882 abstract "This chapter outlines the rationale and experimental approach in the use of the protein synthesis inhibitor, puromycin, to enhance spinal cord regeneration and discuss its effects in relation to the causes of abortive regeneration in the mammalian central nervous system. The chapter reviews the action of puromycin in the injured spinal cord. Inhibition of protein synthesis for a period of 6-24 hour after spinal cord injury has long-lasting consequences. These data indicate that the central nervous system is in a continual state of growth. Inhibition of protein synthesis results in suppression of pathological responses but allows for the continuation of the normal growth processes in the injured spinal cord resulting in transient growth of nerve fibers into the site of spinal cord injury." @default.
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- W61853882 date "1980-01-01" @default.
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- W61853882 title "Puromycin Induction of Transient Regeneration in Mammalian Spinal Cord" @default.
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- W61853882 doi "https://doi.org/10.1016/s0079-6123(08)60055-2" @default.
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