Matches in SemOpenAlex for { <https://semopenalex.org/work/W618568411> ?p ?o ?g. }
- W618568411 abstract "The reduced engraftment potential of cytokine cultured haemopoietic stem/progenitor cells from adult mobilised peripheral blood has been associated with their defective homing to bone marrow niches. In this work, using established in vivo systems and a novel ex vivo model, an additional cytokine-induced attachment defect is described that reduces the retention of these cells in the bone marrow, post-transplantation. This defect was found to be related to specific niche ligands and was not caused by downregulation of their respective receptors on the expanded cells. CD26 is a protease that cleaves SDF-1 abrogating its chemotactic effect. CD26 inhibition on the transplanted cells was not sufficient to reverse the engraftment defect, although infusion of the inhibitor in immunodeficient animals, together with ex vivo treated cells, significantly increased engraftment. Finally, mobilised peripheral blood stem/progenitor cells were found to express neuroreceptors and their expression was altered after exposure to cytokines. Epinephrine pre-treatment of these cells rescued their adhesion to specific niche ligands, increased their short-term homing and improved their long-term engraftment in immunodeficient animals." @default.
- W618568411 created "2016-06-24" @default.
- W618568411 creator A5047684835 @default.
- W618568411 date "2013-04-28" @default.
- W618568411 modified "2023-09-26" @default.
- W618568411 title "Mechanisms underlying cytokine-induced changes in homing and engraftment of human haemopoietic stem and progenitor cells" @default.
- W618568411 cites W104167283 @default.
- W618568411 cites W106229536 @default.
- W618568411 cites W108504518 @default.
- W618568411 cites W109001291 @default.
- W618568411 cites W111579193 @default.
- W618568411 cites W1211643602 @default.
- W618568411 cites W1214205619 @default.
- W618568411 cites W124001930 @default.
- W618568411 cites W1267977458 @default.
- W618568411 cites W12963118 @default.
- W618568411 cites W131495626 @default.
- W618568411 cites W134011100 @default.
- W618568411 cites W134922517 @default.
- W618568411 cites W144006178 @default.
- W618568411 cites W1481422886 @default.
- W618568411 cites W1485136427 @default.
- W618568411 cites W1493925797 @default.
- W618568411 cites W1503737677 @default.
- W618568411 cites W1504660023 @default.
- W618568411 cites W1507630357 @default.
- W618568411 cites W1509594063 @default.
- W618568411 cites W1510771960 @default.
- W618568411 cites W1514456452 @default.
- W618568411 cites W151805421 @default.
- W618568411 cites W1520676690 @default.
- W618568411 cites W1526323145 @default.
- W618568411 cites W1532087698 @default.
- W618568411 cites W1534278651 @default.
- W618568411 cites W153436937 @default.
- W618568411 cites W1538762819 @default.
- W618568411 cites W154306038 @default.
- W618568411 cites W1545476994 @default.
- W618568411 cites W1548081699 @default.
- W618568411 cites W1549257184 @default.
- W618568411 cites W1551102474 @default.
- W618568411 cites W1552274890 @default.
- W618568411 cites W1554718783 @default.
- W618568411 cites W15592170 @default.
- W618568411 cites W1561478198 @default.
- W618568411 cites W1567858186 @default.
- W618568411 cites W1567872738 @default.
- W618568411 cites W1573384321 @default.
- W618568411 cites W1577146075 @default.
- W618568411 cites W1587940136 @default.
- W618568411 cites W1588382160 @default.
- W618568411 cites W1588840730 @default.
- W618568411 cites W1591193872 @default.
- W618568411 cites W1596473475 @default.
- W618568411 cites W1602106002 @default.
- W618568411 cites W1605872454 @default.
- W618568411 cites W1611988858 @default.
- W618568411 cites W1642524132 @default.
- W618568411 cites W165253852 @default.
- W618568411 cites W173907651 @default.
- W618568411 cites W174869347 @default.
- W618568411 cites W176189142 @default.
- W618568411 cites W177057739 @default.
- W618568411 cites W1779237600 @default.
- W618568411 cites W1782832442 @default.
- W618568411 cites W180446930 @default.
- W618568411 cites W1826880678 @default.
- W618568411 cites W1861988602 @default.
- W618568411 cites W1867426767 @default.
- W618568411 cites W1880227053 @default.
- W618568411 cites W1887153402 @default.
- W618568411 cites W1918603815 @default.
- W618568411 cites W192939105 @default.
- W618568411 cites W1932316892 @default.
- W618568411 cites W1940480041 @default.
- W618568411 cites W195788402 @default.
- W618568411 cites W1963984954 @default.
- W618568411 cites W1964952782 @default.
- W618568411 cites W1965734178 @default.
- W618568411 cites W1966092598 @default.
- W618568411 cites W1966973806 @default.
- W618568411 cites W1967250460 @default.
- W618568411 cites W1967608036 @default.
- W618568411 cites W1968628080 @default.
- W618568411 cites W1968736434 @default.
- W618568411 cites W1969073074 @default.
- W618568411 cites W1969084423 @default.
- W618568411 cites W1969219224 @default.
- W618568411 cites W1970366578 @default.
- W618568411 cites W1970824575 @default.
- W618568411 cites W1971505103 @default.
- W618568411 cites W1971588558 @default.
- W618568411 cites W1972044265 @default.
- W618568411 cites W1972103257 @default.
- W618568411 cites W1972114064 @default.
- W618568411 cites W1972224144 @default.
- W618568411 cites W1972279787 @default.
- W618568411 cites W1973035870 @default.
- W618568411 cites W1973474881 @default.
- W618568411 cites W1974342547 @default.