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- W6186210 abstract "Action potentials are a basic and fast communication mode within or in between neuronal and muscular cells in the human body. The rhythmic initiation and structured propagation of action potentials in the heart are most essential for a vital organism. The use of genetically encoded biosensors based on fluorescent proteins allows a non-invasive biocompatible way to read-out action potentials in cardiac myocytes. This comprises the physiological situation as well as pathophysiological models of the diseased heart. Although the approaches to design such biosensors date back to the time when the first fluorescent protein-based FRET sensors were constructed, it took 15 years until first reliable sensors became available. In this chapter, it is shown in cardiac myocytes how fluorescent protein-based action potential measurements can be used in pharmacological screening applications as well as in basic biomedical research. Potentials and limitations will be discussed and perspectives of possible future developments will be provided." @default.
- W6186210 created "2016-06-24" @default.
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- W6186210 date "2011-01-01" @default.
- W6186210 modified "2023-10-13" @default.
- W6186210 title "Action Potentials in Heart Cells" @default.
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- W6186210 doi "https://doi.org/10.1007/4243_2011_28" @default.
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