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- W61864613 abstract "Publisher Summary This chapter discusses the tremorgenic agents and brain acetylcholine. The most important role of the tremorgenic agents can well be the light they may be able to throw upon transmission in the central nervous system. Acetylcholine was the only brain amine which in experience could be appreciably influenced by the tremorgenic agents during the period of tremor. The time of tremor activity also roughly corresponds to the rise in brain acetylcholine. In all three instances the peak activity of the tremor occurs, however, before that of brain acetylcholine. This is most marked with the long acting compound tremorine that has been proven to be metabolized in the body. It is less evident with oxotremorine and arecoline. On the other hand, the rise in tremor activity is concomitant with the rise in brain acetylcholine. Dose–response curves with regard to increase in brain acetylcholine were established for all three agents. Arecoline was most potent in this respect increasing brain acetylcholine to about 25 μ moles per gram tissue." @default.
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- W61864613 title "TREMORGENIC AGENTS AND BRAIN ACETYLCHOLINE" @default.
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