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- W61915504 abstract "Publisher Summary Most patients with esophageal cancer are treated in specialized institutes and staged by endoscopic ultrasonography (EUS), computed tomography (CT) of the chest and abdomen, and ultrasound examination (US) of the cervical region. These traditional methods for staging esophageal cancer have limited sensitivity and specificity. The presence of distant metastases prior to surgery is relatively high, as indicated by detection of metastases during operation in ∼25% of the patients. Positron emission tomography (PET) using 18F-fluorodeoxyglucose (FDG) is a noninvasive metabolic imaging technique, and its usefulness has been established for a number of malignancies. This is the most widely used tracer for staging tumors with PET. It is a glucose analog that enters the cells via the same membrane transporters as glucose. Glucose as well as 18F-FDG are phosphorylated by the enzyme hexokinase. In contrast to glucose-6-phosphate, 18F-FDG-6-phosphate is not a substrate for further metabolism in the glycolytic pathway. Therefore, 18F-FDG-6-phosphate is trapped in the cells in proportion to their glycolytic activity. There is evidence for improved preoperative staging of esophageal cancer with 18F-FDG-PET; sensitivities of 67-74% have been reported, especially with regard to the detection of nonregional lymphatic. Although these results may indicate an important role for 18F-FDG-PET, 18F-FDG is not a tumor-specific tracer and false-positive results may occur." @default.
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- W61915504 date "2008-01-01" @default.
- W61915504 modified "2023-10-17" @default.
- W61915504 title "Esophageal cancer" @default.
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- W61915504 doi "https://doi.org/10.1016/b978-012374212-4.50109-7" @default.
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