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- W61918986 abstract "To investigate the mRNA and protein expression of SMN gene in neuron-like cells by inducing MSC to differentiate into neuron-like cells.Human MSC (hMSC) were isolated and purified. Human MSC were treated with basic fibroblast growth factor (bFGF) before inducing hMSC to differentiate into neuron-like cells with dimethylsulfoxide (DMSO) and butylated hydroxyanisole (BHA). The expression of NSE, NF, and SMN protein in neuron-like cells were detected by immunohistochemistry. The expression of SMN mRNA were detected with reverse transcription-polymerase chain reaction (RT-PCR).Human MSC progressively assumed neuronal morphological characteristics after being induced for 3 hours. Cell bodies had long process contacting with each other. The neuronal marker of NSE and NF was positive in neuron-like cells. Both hMSC and neuron-like cells expressed the mRNA of SMN gene. Compared with hMSC the latter expressed highly the mRNA of SMN gene and it was significance (P < 0.01). SMN protein was only expressed in neuron-like cells.Human MSC are able to differentiate into neuron-like cells with expressing the neuronal marker. Neuron-like cells can express highly the mRNA of SMN gene and express SMN protein." @default.
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- W61918986 date "2005-04-27" @default.
- W61918986 modified "2023-10-06" @default.
- W61918986 title "[Human mesenchymal stem cells differentiate into neuron-like cells and show SMN protein expression]." @default.
- W61918986 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16029573" @default.
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