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- W61931818 endingPage "711" @default.
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- W61931818 abstract "The concept of isosteric replacement and the derived concept of bioisosterism play a major role in the search for analogues of an active drug molecule. The claimed objective of analogue design is to produce improved versions of the pioneer drugs; sometimes, however, compounds with modified pharmacological profile and even with antagonistic properties are obtained.Isosteric replacement requires substitution of one atom or group of atoms in the parent compound by another, with similar electronic and steric configuration. Typical examples of isosteric replacement are given by replacement of an oxygen atom by the NH or CH2 isosteric equivalents. Other examples also result from simple exchanges of atoms or functional groups.The term bioisosterism is used to describe replacements of generally more important pieces of the original molecule. Thus, the replacement of the methylated carboxamide function of diazepam by its bioequivalent methylated triazole group in alprazolam preserves the high affinity for the central benzodiazepinone receptor. Another example worthy of note is the replacement of the ester group by an oxadiazole ring.Finally, taken in its broadest meaning, bioisosterism can consist in a complete replacement of the initial molecular structure by another one, isofunctional, but based on a different scaffold. This approach, called scaffold hopping, is illustrated by the passage of diazepam to zolpidem and to zopiclone. Scaffold hopping can thus be considered as an extreme application of the bioisosterism concept." @default.
- W61931818 created "2016-06-24" @default.
- W61931818 creator A5009844356 @default.
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- W61931818 creator A5036003749 @default.
- W61931818 date "2007-01-01" @default.
- W61931818 modified "2023-09-25" @default.
- W61931818 title "Bioisosterism" @default.
- W61931818 cites W1540956208 @default.
- W61931818 cites W1570961109 @default.
- W61931818 cites W1601059238 @default.
- W61931818 cites W1678749080 @default.
- W61931818 cites W1951658941 @default.
- W61931818 cites W1964119078 @default.
- W61931818 cites W1965527805 @default.
- W61931818 cites W1965676587 @default.
- W61931818 cites W1965730845 @default.
- W61931818 cites W1965743046 @default.
- W61931818 cites W1965774794 @default.
- W61931818 cites W1967479912 @default.
- W61931818 cites W1967909194 @default.
- W61931818 cites W1969791586 @default.
- W61931818 cites W1972022583 @default.
- W61931818 cites W1973220101 @default.
- W61931818 cites W1973633738 @default.
- W61931818 cites W1973872805 @default.
- W61931818 cites W1973874929 @default.
- W61931818 cites W1975596374 @default.
- W61931818 cites W1975602880 @default.
- W61931818 cites W1976694969 @default.
- W61931818 cites W1977158511 @default.
- W61931818 cites W1979715436 @default.
- W61931818 cites W1980235926 @default.
- W61931818 cites W1980612042 @default.
- W61931818 cites W1980696694 @default.
- W61931818 cites W1981305008 @default.
- W61931818 cites W1982005887 @default.
- W61931818 cites W1982927388 @default.
- W61931818 cites W1983759759 @default.
- W61931818 cites W1985832115 @default.
- W61931818 cites W1987424526 @default.
- W61931818 cites W1988518808 @default.
- W61931818 cites W1989293290 @default.
- W61931818 cites W1989294349 @default.
- W61931818 cites W1989359000 @default.
- W61931818 cites W1989390776 @default.
- W61931818 cites W1989713943 @default.
- W61931818 cites W1989874160 @default.
- W61931818 cites W1990957524 @default.
- W61931818 cites W1991320052 @default.
- W61931818 cites W1992394739 @default.
- W61931818 cites W1993231427 @default.
- W61931818 cites W1993624584 @default.
- W61931818 cites W1993814749 @default.
- W61931818 cites W1993836978 @default.
- W61931818 cites W1994797330 @default.
- W61931818 cites W1995534471 @default.
- W61931818 cites W1995944520 @default.
- W61931818 cites W1996194071 @default.
- W61931818 cites W1996930639 @default.
- W61931818 cites W1997343604 @default.
- W61931818 cites W1998395630 @default.
- W61931818 cites W1998638142 @default.
- W61931818 cites W2000208781 @default.
- W61931818 cites W2004448189 @default.
- W61931818 cites W2005373389 @default.
- W61931818 cites W2006898639 @default.
- W61931818 cites W2006989966 @default.
- W61931818 cites W2008078492 @default.
- W61931818 cites W2008536525 @default.
- W61931818 cites W2009448561 @default.
- W61931818 cites W2010398646 @default.
- W61931818 cites W2010425214 @default.
- W61931818 cites W2010433936 @default.
- W61931818 cites W2012864164 @default.
- W61931818 cites W2013252397 @default.
- W61931818 cites W2014279363 @default.
- W61931818 cites W2014677805 @default.
- W61931818 cites W2016158798 @default.
- W61931818 cites W2016497762 @default.
- W61931818 cites W2018033128 @default.
- W61931818 cites W2018572069 @default.
- W61931818 cites W2018701979 @default.
- W61931818 cites W2019405291 @default.
- W61931818 cites W2019563519 @default.
- W61931818 cites W2020200168 @default.
- W61931818 cites W2020383361 @default.
- W61931818 cites W2021340911 @default.
- W61931818 cites W2023613938 @default.
- W61931818 cites W2023660580 @default.
- W61931818 cites W2023822951 @default.
- W61931818 cites W2023942953 @default.
- W61931818 cites W2024534943 @default.
- W61931818 cites W2025453958 @default.
- W61931818 cites W2026644866 @default.
- W61931818 cites W2027214846 @default.
- W61931818 cites W2027366488 @default.