Matches in SemOpenAlex for { <https://semopenalex.org/work/W619336144> ?p ?o ?g. }
Showing items 1 to 64 of
64
with 100 items per page.
- W619336144 abstract "Intensive research over the past 2 decades has implicated ceramide, a bioactive sphingolipid, in the regulation of apoptosis, cell growth, cell senescence, and inflammation. Emerging evidence, however, is pointing to significant complexities in the metabolism and structure of ceramide with multiple pathways mediated by more than 2 dozen distinct enzymes of ceramide metabolism regulating the formation of ceramide. Indeed, ceramide itself constitutes a family of closely-related molecules that are distinguished by specific modifications (e.g. chain length of acyl and sphingoid groups, hydroxylations, specific double bonds). These concepts are well illustrated by studies on acid and neutral sphingomyelinases, two key enzymes in ceramide formation. Neutral sphingomyelinases exist in the inner leaflet of the plasma membrane and mitochondria whereas acid sphingomyelinase resides in the lysosome but is also seen extracellularly and in secretory vesicles. Ongoing results suggest unique functions for each subcellular localization of these enzymes that appear to be mediated through distinct ceramides. Thus, studies of ‘ceramide’ are best approached as enzyme- and lipid-specific pathways of cell regulation." @default.
- W619336144 created "2016-06-24" @default.
- W619336144 creator A5090422329 @default.
- W619336144 date "2011-04-01" @default.
- W619336144 modified "2023-09-25" @default.
- W619336144 title "Sphingomyelinases in the regulation of ceramide formation and function" @default.
- W619336144 doi "https://doi.org/10.1096/fasebj.25.1_supplement.191.1" @default.
- W619336144 hasPublicationYear "2011" @default.
- W619336144 type Work @default.
- W619336144 sameAs 619336144 @default.
- W619336144 citedByCount "0" @default.
- W619336144 crossrefType "journal-article" @default.
- W619336144 hasAuthorship W619336144A5090422329 @default.
- W619336144 hasConcept C180899940 @default.
- W619336144 hasConcept C181199279 @default.
- W619336144 hasConcept C185592680 @default.
- W619336144 hasConcept C190283241 @default.
- W619336144 hasConcept C2777851122 @default.
- W619336144 hasConcept C2779237115 @default.
- W619336144 hasConcept C2780216420 @default.
- W619336144 hasConcept C2781070647 @default.
- W619336144 hasConcept C2781457462 @default.
- W619336144 hasConcept C28859421 @default.
- W619336144 hasConcept C41625074 @default.
- W619336144 hasConcept C55493867 @default.
- W619336144 hasConcept C61322309 @default.
- W619336144 hasConcept C61705674 @default.
- W619336144 hasConcept C86803240 @default.
- W619336144 hasConcept C95444343 @default.
- W619336144 hasConceptScore W619336144C180899940 @default.
- W619336144 hasConceptScore W619336144C181199279 @default.
- W619336144 hasConceptScore W619336144C185592680 @default.
- W619336144 hasConceptScore W619336144C190283241 @default.
- W619336144 hasConceptScore W619336144C2777851122 @default.
- W619336144 hasConceptScore W619336144C2779237115 @default.
- W619336144 hasConceptScore W619336144C2780216420 @default.
- W619336144 hasConceptScore W619336144C2781070647 @default.
- W619336144 hasConceptScore W619336144C2781457462 @default.
- W619336144 hasConceptScore W619336144C28859421 @default.
- W619336144 hasConceptScore W619336144C41625074 @default.
- W619336144 hasConceptScore W619336144C55493867 @default.
- W619336144 hasConceptScore W619336144C61322309 @default.
- W619336144 hasConceptScore W619336144C61705674 @default.
- W619336144 hasConceptScore W619336144C86803240 @default.
- W619336144 hasConceptScore W619336144C95444343 @default.
- W619336144 hasIssue "S1" @default.
- W619336144 hasLocation W6193361441 @default.
- W619336144 hasOpenAccess W619336144 @default.
- W619336144 hasPrimaryLocation W6193361441 @default.
- W619336144 hasRelatedWork W1492356485 @default.
- W619336144 hasRelatedWork W1978496843 @default.
- W619336144 hasRelatedWork W1995126002 @default.
- W619336144 hasRelatedWork W2003146474 @default.
- W619336144 hasRelatedWork W2013036626 @default.
- W619336144 hasRelatedWork W2041922728 @default.
- W619336144 hasRelatedWork W3046828761 @default.
- W619336144 hasRelatedWork W3172495542 @default.
- W619336144 hasRelatedWork W4320484043 @default.
- W619336144 hasRelatedWork W44964377 @default.
- W619336144 hasVolume "25" @default.
- W619336144 isParatext "false" @default.
- W619336144 isRetracted "false" @default.
- W619336144 magId "619336144" @default.
- W619336144 workType "article" @default.