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- W61944442 abstract "Hyperthermia can increase intestinal permeability, often contributing to severe heat illness. Previous work has shown that baicalein is protective of barrier integrity in hyperthermia. Since baicalein is both a 12/15-lipoxygenase (LOX) inhibitor and an antioxidant, the mechanism of action is not understood. This study tested whether other LOX inhibitors, ETYA and LOXBlock-1 were protective. LOXBlock-1 does not have antioxidant properties. Intestinal segments of adult mice were isolated and everted to create ~8 × 2 cm sacs. These were treated with the LOX inhibitors, ETYA (0, 10, 20, and 50 μM) or LOXBlock-1 (0, 10, 20, and 40 μM). All tissues were first incubated at 37± 0.5°C for 30 min with the drugs. Then temperature was increased to 42± 0.5°C for 90 min. Permeability was measured by accumulation of fluorescent labeled dextran (4kDal) that diffused into the sacs. Compared to control segments (42°C), ETYA significantly increased permeability (P<0.02). A similar trend was seen for LOXBlock-1. Thus, in contrast to baicalein, no protection of barrier integrity was observed during hyperthermia with 12/15 LOX inhibitors and in most cases LOX inhibition worsened barrier function. This suggests that normal LOX function is critical for maintaining intestinal barrier in hyperthermia and that baicalein's protective effects must be related to other mechanisms such as its known antioxidant actions. NHLBI 53333" @default.
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- W61944442 date "2010-04-01" @default.
- W61944442 modified "2023-09-23" @default.
- W61944442 title "Protection of the intestinal barrier in hyperthermia: defining the role of 12/15‐lipoxygenase." @default.
- W61944442 doi "https://doi.org/10.1096/fasebj.24.1_supplement.1004.8" @default.
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