FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W61946602> ?p ?o ?g. }

• W61946602 endingPage "73" @default.
• W61946602 startingPage "63" @default.
• W61946602 abstract "Abstract Chemoprevention using isothiocyanates is partly the result of the induction of phase II enzymes for carcinogen detoxification from healthy cells. However, phase II enzyme activity can impair cancer therapeutic agents. The objective of this study was to assess phase II enzyme induction and cytotoxicity of phenethyl isothiocyanate (PEITC) and glutathione conjugate with PEITC (GsPEITC) using MCF-7 and MDA-MB-231 breast cancer cells. Changes of phase II enzymes, glutathione-S-transferase (GST) and NAD(P)H quinone reductase (QR), were measured by colorimetric procedures. Cell viability was determined using the MTT (3-(4,5-Dimethylthiazol-2-yl)-2,5-di-phenyltetrazolium- bromide) assay. From current results, 24hr exposure to <5 μM of PEITC or GsPEITC was not cytotoxic to breast cancer cells. No significant induction of phase II enzyme occurred with a low dose range. By contrast, MCF-7 viability decreased by 50% following 24 hr treatment with 42 ±0.5 µM PEITC or 19. ±0.1 µM GsPEITC. The concentrations for 50% loss of viability (IC50) were 103±0.5 µM PEITC and 32±0.5 µM GsPEITC in tests using MDA-MB-231 cells. Thus, MCF-7 cells were" @default.
• W61946602 created "2016-06-24" @default.
• W61946602 creator A5061712003 @default.
• W61946602 creator A5088759564 @default.
• W61946602 date "2013-01-01" @default.
• W61946602 modified "2023-09-27" @default.
• W61946602 title "Enzyme induction and cytotoxicity of phenethyl isothiocyanate and its glutathione conjugate towards breast cancer cells" @default.
• W61946602 cites W1555545433 @default.
• W61946602 cites W1581414347 @default.
• W61946602 cites W1801772329 @default.
• W61946602 cites W1815349537 @default.
• W61946602 cites W1973143071 @default.
• W61946602 cites W1973275034 @default.
• W61946602 cites W1974726848 @default.
• W61946602 cites W1975773180 @default.
• W61946602 cites W1978018487 @default.
• W61946602 cites W2009783875 @default.
• W61946602 cites W2011909018 @default.
• W61946602 cites W2013485244 @default.
• W61946602 cites W2018693799 @default.
• W61946602 cites W2036895770 @default.
• W61946602 cites W2046005603 @default.
• W61946602 cites W2054251983 @default.
• W61946602 cites W2063944482 @default.
• W61946602 cites W2077956306 @default.
• W61946602 cites W2106746185 @default.
• W61946602 cites W2116101826 @default.
• W61946602 cites W2122765586 @default.
• W61946602 cites W2127558577 @default.
• W61946602 cites W2147144053 @default.
• W61946602 cites W2148422042 @default.
• W61946602 cites W2169596089 @default.
• W61946602 cites W29440846 @default.
• W61946602 doi "https://doi.org/10.12988/pacs.2013.3514" @default.
• W61946602 hasPublicationYear "2013" @default.
• W61946602 type Work @default.
• W61946602 sameAs 61946602 @default.
• W61946602 citedByCount "3" @default.
• W61946602 countsByYear W619466022014 @default.
• W61946602 countsByYear W619466022015 @default.
• W61946602 crossrefType "journal-article" @default.
• W61946602 hasAuthorship W61946602A5061712003 @default.
• W61946602 hasAuthorship W61946602A5088759564 @default.
• W61946602 hasConcept C109316439 @default.
• W61946602 hasConcept C121608353 @default.
• W61946602 hasConcept C126322002 @default.
• W61946602 hasConcept C165069038 @default.
• W61946602 hasConcept C181199279 @default.
• W61946602 hasConcept C185592680 @default.
• W61946602 hasConcept C190283241 @default.
• W61946602 hasConcept C202751555 @default.
• W61946602 hasConcept C2776572452 @default.
• W61946602 hasConcept C2778760513 @default.
• W61946602 hasConcept C2780740852 @default.
• W61946602 hasConcept C53227056 @default.
• W61946602 hasConcept C538909803 @default.
• W61946602 hasConcept C55493867 @default.
• W61946602 hasConcept C71924100 @default.
• W61946602 hasConcept C86803240 @default.
• W61946602 hasConcept C96232424 @default.
• W61946602 hasConcept C98274493 @default.
• W61946602 hasConceptScore W61946602C109316439 @default.
• W61946602 hasConceptScore W61946602C121608353 @default.
• W61946602 hasConceptScore W61946602C126322002 @default.
• W61946602 hasConceptScore W61946602C165069038 @default.
• W61946602 hasConceptScore W61946602C181199279 @default.
• W61946602 hasConceptScore W61946602C185592680 @default.
• W61946602 hasConceptScore W61946602C190283241 @default.
• W61946602 hasConceptScore W61946602C202751555 @default.
• W61946602 hasConceptScore W61946602C2776572452 @default.
• W61946602 hasConceptScore W61946602C2778760513 @default.
• W61946602 hasConceptScore W61946602C2780740852 @default.
• W61946602 hasConceptScore W61946602C53227056 @default.
• W61946602 hasConceptScore W61946602C538909803 @default.
• W61946602 hasConceptScore W61946602C55493867 @default.
• W61946602 hasConceptScore W61946602C71924100 @default.
• W61946602 hasConceptScore W61946602C86803240 @default.
• W61946602 hasConceptScore W61946602C96232424 @default.
• W61946602 hasConceptScore W61946602C98274493 @default.
• W61946602 hasLocation W619466021 @default.
• W61946602 hasOpenAccess W61946602 @default.
• W61946602 hasPrimaryLocation W619466021 @default.
• W61946602 hasRelatedWork W1602610985 @default.
• W61946602 hasRelatedWork W2008453600 @default.
• W61946602 hasRelatedWork W2034451172 @default.
• W61946602 hasRelatedWork W2060435293 @default.
• W61946602 hasRelatedWork W2062114851 @default.
• W61946602 hasRelatedWork W2115341251 @default.
• W61946602 hasRelatedWork W2187672159 @default.
• W61946602 hasRelatedWork W2255287849 @default.
• W61946602 hasRelatedWork W2605736820 @default.
• W61946602 hasRelatedWork W2889473750 @default.
• W61946602 hasRelatedWork W2892172652 @default.
• W61946602 hasRelatedWork W2914191264 @default.
• W61946602 hasRelatedWork W2922276278 @default.
• W61946602 hasRelatedWork W2953299238 @default.
• W61946602 hasRelatedWork W2992677533 @default.
• W61946602 hasRelatedWork W3012513420 @default.

• next