FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W619479224> ?p ?o ?g. }

• W619479224 endingPage "15" @default.
• W619479224 startingPage "1" @default.
• W619479224 abstract "The immune response is an important component of the cochlear response to stress. As an important player in the cochlear immune system, the basilar membrane immune cells reside on the surface of the scala tympani side of the basilar membrane. At present, the immune cell properties in this region and their responses to stress are not well understood. Here, we investigated the functional role of these immune cells in the immune response to acoustic overstimulation. This study reveals that tissue macrophages are present in the entire length of the basilar membrane under steady-state conditions. Notably, these cells in the apical and the basal sections of the basilar membrane display distinct morphologies and immune protein expression patterns. Following acoustic trauma, monocytes infiltrate into the region of the basilar membrane, and the infiltrated cells transform into macrophages. While monocyte infiltration and transformation occur in both the apical and the basal sections of the basilar membrane, only the basal monocytes and macrophages display a marked increase in the expression of major histocompatibility complex (MHC) II and class II transactivator (CIITA), a MHC II production cofactor, suggesting the site-dependent activation of antigen-presenting function. Consistent with the increased expression of the antigen-presenting proteins, CD4(+) T cells, the antigen-presenting partner, infiltrate into the region of the basilar membrane where antigen-presenting proteins are upregulated. Further pathological analyses revealed that the basal section of the cochlea displays a greater level of sensory cell damage, which is spatially correlated with the region of antigen-presenting activity. Together, these results suggest that the antigen-presenting function of the mononuclear phagocyte population is activated in response to acoustic trauma, which could bridge the innate immune response to adaptive immunity." @default.
• W619479224 created "2016-06-24" @default.
• W619479224 creator A5030340580 @default.
• W619479224 creator A5045372327 @default.
• W619479224 creator A5050170123 @default.
• W619479224 creator A5072854024 @default.
• W619479224 creator A5090083984 @default.
• W619479224 date "2015-09-01" @default.
• W619479224 modified "2023-10-16" @default.
• W619479224 title "Activation of the antigen presentation function of mononuclear phagocyte populations associated with the basilar membrane of the cochlea after acoustic overstimulation" @default.
• W619479224 cites W1927383279 @default.
• W619479224 cites W1967888989 @default.
• W619479224 cites W1981593238 @default.
• W619479224 cites W1983851734 @default.
• W619479224 cites W1985130877 @default.
• W619479224 cites W1996202980 @default.
• W619479224 cites W2000352929 @default.
• W619479224 cites W2003555014 @default.
• W619479224 cites W2005154068 @default.
• W619479224 cites W2007549963 @default.
• W619479224 cites W2009291568 @default.
• W619479224 cites W2020549109 @default.
• W619479224 cites W2021950845 @default.
• W619479224 cites W2022381635 @default.
• W619479224 cites W2026239990 @default.
• W619479224 cites W2029444903 @default.
• W619479224 cites W2031729846 @default.
• W619479224 cites W2037282849 @default.
• W619479224 cites W2041772815 @default.
• W619479224 cites W2045032466 @default.
• W619479224 cites W2046207757 @default.
• W619479224 cites W2047083034 @default.
• W619479224 cites W2048500450 @default.
• W619479224 cites W2048579894 @default.
• W619479224 cites W2051300727 @default.
• W619479224 cites W2060320549 @default.
• W619479224 cites W2064462967 @default.
• W619479224 cites W2068264180 @default.
• W619479224 cites W2074544814 @default.
• W619479224 cites W2078291178 @default.
• W619479224 cites W2093143038 @default.
• W619479224 cites W2096598170 @default.
• W619479224 cites W2111504178 @default.
• W619479224 cites W2112093664 @default.
• W619479224 cites W2112863126 @default.
• W619479224 cites W2117941191 @default.
• W619479224 cites W2125841464 @default.
• W619479224 cites W2132864045 @default.
• W619479224 cites W2132981330 @default.
• W619479224 cites W2134364025 @default.
• W619479224 cites W2134661135 @default.
• W619479224 cites W2138397958 @default.
• W619479224 cites W2141512146 @default.
• W619479224 cites W2145049340 @default.
• W619479224 cites W2161991472 @default.
• W619479224 cites W2177327503 @default.
• W619479224 cites W2314456977 @default.
• W619479224 cites W4231068105 @default.
• W619479224 cites W4239176618 @default.
• W619479224 doi "https://doi.org/10.1016/j.neuroscience.2015.05.081" @default.
• W619479224 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4532582" @default.
• W619479224 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26102003" @default.
• W619479224 hasPublicationYear "2015" @default.
• W619479224 type Work @default.
• W619479224 sameAs 619479224 @default.
• W619479224 citedByCount "71" @default.
• W619479224 countsByYear W6194792242016 @default.
• W619479224 countsByYear W6194792242017 @default.
• W619479224 countsByYear W6194792242018 @default.
• W619479224 countsByYear W6194792242019 @default.
• W619479224 countsByYear W6194792242020 @default.
• W619479224 countsByYear W6194792242021 @default.
• W619479224 countsByYear W6194792242022 @default.
• W619479224 countsByYear W6194792242023 @default.
• W619479224 crossrefType "journal-article" @default.
• W619479224 hasAuthorship W619479224A5030340580 @default.
• W619479224 hasAuthorship W619479224A5045372327 @default.
• W619479224 hasAuthorship W619479224A5050170123 @default.
• W619479224 hasAuthorship W619479224A5072854024 @default.
• W619479224 hasAuthorship W619479224A5090083984 @default.
• W619479224 hasBestOaLocation W6194792242 @default.
• W619479224 hasConcept C147483822 @default.
• W619479224 hasConcept C169760540 @default.
• W619479224 hasConcept C185592680 @default.
• W619479224 hasConcept C203014093 @default.
• W619479224 hasConcept C2776090121 @default.
• W619479224 hasConcept C2780130748 @default.
• W619479224 hasConcept C2780807236 @default.
• W619479224 hasConcept C83464605 @default.
• W619479224 hasConcept C86803240 @default.
• W619479224 hasConcept C8891405 @default.
• W619479224 hasConcept C95444343 @default.
• W619479224 hasConceptScore W619479224C147483822 @default.
• W619479224 hasConceptScore W619479224C169760540 @default.
• W619479224 hasConceptScore W619479224C185592680 @default.
• W619479224 hasConceptScore W619479224C203014093 @default.
• W619479224 hasConceptScore W619479224C2776090121 @default.
• W619479224 hasConceptScore W619479224C2780130748 @default.

• next