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- W619589014 abstract "The aim of this project was to develop injectable materials to repair damagedbone and, to simultaneously release antibacterial drugs and genes in acontrollable manner. Fluid poly (propylene glycol -co- lactide) dimethacrylate(PGLA-DMA) was first synthesised and then filled with varying levels of β-tricalcium phosphate (β-TCP) and monocalcium phosphate monohydrate(MCPM) to fabricate composite materials.For all formulations (including polymer and composites), full methacrylateconversion was found to occur within 200 s of exposure to blue light. Theinitial dry polymer modulus was enhanced three-fold by increasing total fillercontent to 70%. After composite immersion in water, β-TCP and MCPM wasfound to react and re-precipitate within the set materials as dicalciumphosphate (DCP, i.e. brushite and monetite). At higher MCPM levels therewas an increase in DCP formation, composite degradation rate, release ofboth calcium and phosphate ions and buffering of acidic polymer degradationproducts. Additionally, bone-like MG-63 cells were found to attach, spreadand proliferate on both the polymer and the composite surfaces and,composites implanted into chick embryo femurs demonstrated closeapposition to the host tissue.To examine the potential value for drug delivery, both the polymer and thecomposites were prepared containing 10% of the antibacterial chlorhexidine(CHX). The drug was found to be released from material via diffusion, whichincreased along with antibacterial activity when the filler content was raised. PGLA-DMA polymer was additionally prepared containing complexes of thecommercial cationic lipid MetafecteneTM Pro and green fluorescent proteinplasmid DNA. Initial studies demonstrated that the components released fromthe materials were capable of gene transfection into human bone-formingmesenchymal stem cells in vitro.These studies thus demonstrate that the injectable, rapidly settable PGLADMAmaterials produced here might have clinical potential as both boneadhesives and drug delivery devices." @default.
- W619589014 created "2016-06-24" @default.
- W619589014 creator A5045242820 @default.
- W619589014 date "2010-12-28" @default.
- W619589014 modified "2023-09-26" @default.
- W619589014 title "Injectable degradable composite materials for bone repair and drug delivery" @default.
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