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- W619703204 endingPage "9965" @default.
- W619703204 startingPage "9954" @default.
- W619703204 abstract "Epidermal growth factor receptor (EGFR) exemplifies the family of receptor tyrosine kinases that mediate numerous cellular processes, including growth, proliferation, and differentiation. Moreover, gene amplification and EGFR mutations have been identified in a number of human malignancies, making this receptor an important target for the development of anticancer drugs. In addition to ligand-dependent activation and concomitant tyrosine phosphorylation, EGFR stimulation results in the localized generation of H2O2 by NADPH-dependent oxidases. In turn, H2O2 functions as a secondary messenger to regulate intracellular signaling cascades, largely through the modification of specific cysteine residues within redox-sensitive protein targets, including Cys797 in the EGFR active site. In this review, we highlight recent advances in our understanding of the mechanisms that underlie redox regulation of EGFR signaling and how these discoveries may form the basis for the development of new therapeutic strategies for targeting this and other H2O2-modulated pathways." @default.
- W619703204 created "2016-06-24" @default.
- W619703204 creator A5030409012 @default.
- W619703204 creator A5042072871 @default.
- W619703204 date "2012-12-05" @default.
- W619703204 modified "2023-09-24" @default.
- W619703204 title "Redox Regulation of Epidermal Growth Factor Receptor Signaling through Cysteine Oxidation" @default.
- W619703204 cites W1444730310 @default.
- W619703204 cites W1492951734 @default.
- W619703204 cites W1501383613 @default.
- W619703204 cites W1510592624 @default.
- W619703204 cites W1512982676 @default.
- W619703204 cites W1525467602 @default.
- W619703204 cites W1548966243 @default.
- W619703204 cites W1561326814 @default.
- W619703204 cites W1569199195 @default.
- W619703204 cites W1638074023 @default.
- W619703204 cites W1639582946 @default.
- W619703204 cites W1811191752 @default.
- W619703204 cites W1836212818 @default.
- W619703204 cites W1921965616 @default.
- W619703204 cites W1934775191 @default.
- W619703204 cites W1940436875 @default.
- W619703204 cites W1964321121 @default.
- W619703204 cites W1964953227 @default.
- W619703204 cites W1968998462 @default.
- W619703204 cites W1969360388 @default.
- W619703204 cites W1969901996 @default.
- W619703204 cites W1969918683 @default.
- W619703204 cites W1970841988 @default.
- W619703204 cites W1970929283 @default.
- W619703204 cites W1972355020 @default.
- W619703204 cites W1972530911 @default.
- W619703204 cites W1973837499 @default.
- W619703204 cites W1973871728 @default.
- W619703204 cites W1975287242 @default.
- W619703204 cites W1981659539 @default.
- W619703204 cites W1983089513 @default.
- W619703204 cites W1989211638 @default.
- W619703204 cites W1989987141 @default.
- W619703204 cites W1991952977 @default.
- W619703204 cites W1992250994 @default.
- W619703204 cites W1994412044 @default.
- W619703204 cites W2008656776 @default.
- W619703204 cites W2009476974 @default.
- W619703204 cites W2009940961 @default.
- W619703204 cites W2010993054 @default.
- W619703204 cites W2011964721 @default.
- W619703204 cites W2013355944 @default.
- W619703204 cites W2014791743 @default.
- W619703204 cites W2017009693 @default.
- W619703204 cites W2017265125 @default.
- W619703204 cites W2019304549 @default.
- W619703204 cites W2020272282 @default.
- W619703204 cites W2021346058 @default.
- W619703204 cites W2025191591 @default.
- W619703204 cites W2030817463 @default.
- W619703204 cites W2031729422 @default.
- W619703204 cites W2036926586 @default.
- W619703204 cites W2037813091 @default.
- W619703204 cites W2038284767 @default.
- W619703204 cites W2038561084 @default.
- W619703204 cites W2039292895 @default.
- W619703204 cites W2041489973 @default.
- W619703204 cites W2042458891 @default.
- W619703204 cites W2043085507 @default.
- W619703204 cites W2044316744 @default.
- W619703204 cites W2047192016 @default.
- W619703204 cites W2048569323 @default.
- W619703204 cites W2051201358 @default.
- W619703204 cites W2053174155 @default.
- W619703204 cites W2054165134 @default.
- W619703204 cites W2056840435 @default.
- W619703204 cites W2057073941 @default.
- W619703204 cites W2061693087 @default.
- W619703204 cites W2062482627 @default.
- W619703204 cites W2062855968 @default.
- W619703204 cites W2063013228 @default.
- W619703204 cites W2063197054 @default.
- W619703204 cites W2066451762 @default.
- W619703204 cites W2067138633 @default.
- W619703204 cites W2067593902 @default.
- W619703204 cites W2068697011 @default.
- W619703204 cites W2070513297 @default.
- W619703204 cites W2071946044 @default.
- W619703204 cites W2072827597 @default.
- W619703204 cites W2073081466 @default.
- W619703204 cites W2076367848 @default.
- W619703204 cites W2077351642 @default.
- W619703204 cites W2077804275 @default.
- W619703204 cites W2077895595 @default.
- W619703204 cites W2080616631 @default.
- W619703204 cites W2085664820 @default.
- W619703204 cites W2088548538 @default.
- W619703204 cites W2088790008 @default.
- W619703204 cites W2091386218 @default.
- W619703204 cites W2093595737 @default.
- W619703204 cites W2094068658 @default.