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- W62017654 abstract "The kinetics of penetration of DMO into intraocular fluids at different plasma levels or after the administration of probenecid or dichlorphenamide have been studied. Many similarities were found to other systems which have been studied. The data provided further evidence for the probability that DMO is secreted out of the eye and that this mechanism is inhibited by probenecid and dichlorphenamide. D, MO penetrates most of the tissues studied by a diffusional process. 1 ' - Although DMO should be in excess in the anterior intraocular fluids of the rabbit because the pH of these fluids is alkaline relative to that of plasma, an excess is seen only when the plasma level is high or the animal has been treated with probenecid or dichlorphenamide. 3 ' l It was of interest to conduct time-course studies under these various conditions to obtain further information concerning the mechanisms of the penetration of DMO into intraocular fluids. Methods" @default.
- W62017654 created "2016-06-24" @default.
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- W62017654 date "1968-06-01" @default.
- W62017654 modified "2023-09-23" @default.
- W62017654 title "Distribution of 5,5-dimethyl-2,4-oxazolidinedione (DMO) in intraocular fluids. V. Effect of plasma level, probenecid, and dichlorphenamide on time course." @default.
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