Matches in SemOpenAlex for { <https://semopenalex.org/work/W620362212> ?p ?o ?g. }
Showing items 1 to 97 of
97
with 100 items per page.
- W620362212 abstract "Autologous fat grafting has been used for reconstructive and aesthetic surgery for more than a century. Although initial criticism involved fat resorption and later the possible radiological interference in mammographies, the most recent debate focuses on the carcinogenicity of fat grafts. Among malignant skin tumors, melanomas show the highest lethality and lead to significant soft tissue defects after resection with fat grafting representing a feasible therapy option for tissue reconstruction. In contrast to breast carcinoma, little data is available regarding the carcinogenicity of fat grafts in melanoma patients. The present study was designed to investigate the influence of whole adipose tissue on the growth of melanoma cell lines compared to breast cancer cell lines.Human subcutaneous adipose tissue was obtained from elective surgeries and cut into pieces ranging from 20 to 500 mg. Adipose tissue samples were co-cultivated with the human breast cancer cell line MCF-7 and the melanoma cell lines MEL-JUSO and IGR-37, and proliferation was measured using the alamarBlue proliferation assay. Additionally, the same experiment was conducted under nutrient-limited conditions.We found that adipose tissue significantly increased the proliferation of the human breast cancer cell line MCF-7 and importantly also of the melanoma cell lines MEL-JUSO and IGR-37 under optimal nutrient supply. Although the impact of adipose tissue on the growth of MCF-7 cells under nutrient deprivation was comparatively weak, the proliferation of MEL-JUSO and IGR-37 cells was clearly stimulated by adipose tissue.Our results show that adipose tissue enhances not only the growth of breast cancer but also melanoma cells even under conditions of nutrient limitation by soluble factors secreted by adipose tissue. With respect to our results and the current literature, reconstruction of soft tissue defects after malignancies including breast cancer and melanoma should be conducted with great care and only after complete tumor resection." @default.
- W620362212 created "2016-06-24" @default.
- W620362212 creator A5013589814 @default.
- W620362212 creator A5024762196 @default.
- W620362212 creator A5042903189 @default.
- W620362212 creator A5053141154 @default.
- W620362212 creator A5065015595 @default.
- W620362212 date "2015-06-01" @default.
- W620362212 modified "2023-09-23" @default.
- W620362212 title "Adipose Tissue Increases the Proliferation of Melanoma Cell Lines In Vitro" @default.
- W620362212 cites W1975821279 @default.
- W620362212 cites W1979679866 @default.
- W620362212 cites W2007615242 @default.
- W620362212 cites W2016607459 @default.
- W620362212 cites W2047873619 @default.
- W620362212 cites W2068700159 @default.
- W620362212 cites W2077246243 @default.
- W620362212 cites W2078338424 @default.
- W620362212 cites W2078569539 @default.
- W620362212 cites W2079613095 @default.
- W620362212 cites W2100224830 @default.
- W620362212 cites W2101619299 @default.
- W620362212 cites W2107402669 @default.
- W620362212 cites W2108471042 @default.
- W620362212 cites W2108886080 @default.
- W620362212 cites W2135126928 @default.
- W620362212 cites W2139599594 @default.
- W620362212 cites W4229949943 @default.
- W620362212 cites W4251749726 @default.
- W620362212 doi "https://doi.org/10.1097/scs.0000000000001593" @default.
- W620362212 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26080206" @default.
- W620362212 hasPublicationYear "2015" @default.
- W620362212 type Work @default.
- W620362212 sameAs 620362212 @default.
- W620362212 citedByCount "3" @default.
- W620362212 countsByYear W6203622122015 @default.
- W620362212 countsByYear W6203622122020 @default.
- W620362212 crossrefType "journal-article" @default.
- W620362212 hasAuthorship W620362212A5013589814 @default.
- W620362212 hasAuthorship W620362212A5024762196 @default.
- W620362212 hasAuthorship W620362212A5042903189 @default.
- W620362212 hasAuthorship W620362212A5053141154 @default.
- W620362212 hasAuthorship W620362212A5065015595 @default.
- W620362212 hasConcept C121608353 @default.
- W620362212 hasConcept C126322002 @default.
- W620362212 hasConcept C142724271 @default.
- W620362212 hasConcept C1491633281 @default.
- W620362212 hasConcept C171089720 @default.
- W620362212 hasConcept C2777658100 @default.
- W620362212 hasConcept C502942594 @default.
- W620362212 hasConcept C530470458 @default.
- W620362212 hasConcept C54355233 @default.
- W620362212 hasConcept C62112901 @default.
- W620362212 hasConcept C71924100 @default.
- W620362212 hasConcept C81885089 @default.
- W620362212 hasConcept C86803240 @default.
- W620362212 hasConceptScore W620362212C121608353 @default.
- W620362212 hasConceptScore W620362212C126322002 @default.
- W620362212 hasConceptScore W620362212C142724271 @default.
- W620362212 hasConceptScore W620362212C1491633281 @default.
- W620362212 hasConceptScore W620362212C171089720 @default.
- W620362212 hasConceptScore W620362212C2777658100 @default.
- W620362212 hasConceptScore W620362212C502942594 @default.
- W620362212 hasConceptScore W620362212C530470458 @default.
- W620362212 hasConceptScore W620362212C54355233 @default.
- W620362212 hasConceptScore W620362212C62112901 @default.
- W620362212 hasConceptScore W620362212C71924100 @default.
- W620362212 hasConceptScore W620362212C81885089 @default.
- W620362212 hasConceptScore W620362212C86803240 @default.
- W620362212 hasLocation W6203622121 @default.
- W620362212 hasLocation W6203622122 @default.
- W620362212 hasOpenAccess W620362212 @default.
- W620362212 hasPrimaryLocation W6203622121 @default.
- W620362212 hasRelatedWork W137311434 @default.
- W620362212 hasRelatedWork W1899107964 @default.
- W620362212 hasRelatedWork W2009547122 @default.
- W620362212 hasRelatedWork W2015716451 @default.
- W620362212 hasRelatedWork W2053938092 @default.
- W620362212 hasRelatedWork W2072579058 @default.
- W620362212 hasRelatedWork W2073482429 @default.
- W620362212 hasRelatedWork W2076046704 @default.
- W620362212 hasRelatedWork W2109169426 @default.
- W620362212 hasRelatedWork W2114336459 @default.
- W620362212 hasRelatedWork W2118992835 @default.
- W620362212 hasRelatedWork W2158024710 @default.
- W620362212 hasRelatedWork W2159979481 @default.
- W620362212 hasRelatedWork W2277983318 @default.
- W620362212 hasRelatedWork W2337878444 @default.
- W620362212 hasRelatedWork W2396709959 @default.
- W620362212 hasRelatedWork W2422519412 @default.
- W620362212 hasRelatedWork W2799399097 @default.
- W620362212 hasRelatedWork W2902704981 @default.
- W620362212 hasRelatedWork W3020607942 @default.
- W620362212 isParatext "false" @default.
- W620362212 isRetracted "false" @default.
- W620362212 magId "620362212" @default.
- W620362212 workType "article" @default.