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- W620370710 abstract "Glioblastoma (GBM, Grade IV astrocytoma) is the most common and most aggressive of the primary malignant brain tumors in adults. Hypoxia is a distinct feature in GBM and plays a significant role in tumor progression, resistance to treatment and poor outcomes. This review considers the effects of hypoxia on astrocytic tumors and the mechanisms that contribute to tumor progression and therapeutic resistance, with a focus on the vascular changes, chemotaxic signaling pathways and metabolic alterations involved." @default.
- W620370710 created "2016-06-24" @default.
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- W620370710 date "2016-01-01" @default.
- W620370710 modified "2023-10-14" @default.
- W620370710 title "Hypoxia in astrocytic tumors and implications for therapy" @default.
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- W620370710 doi "https://doi.org/10.1016/j.nbd.2015.06.007" @default.
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