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- W62055145 abstract "The mouse neurologic mutant Lurcher carries a semidominant genetic lesion that results in severe neurologic dysfunction (Philips 1960). Classical studies have established that the Lurcher mutation results in cell autonomous death of cerebellar Purkinje cells beginning in the second postnatal week (Caddy and Biscoe 1975). We have examined the expression of terminal markers for Purkinje cell differentiation, including the Kv3.3b potassium channel (Goldman-Wohl et al. 1994), and demonstrated that they are expressed prior to cell death in Lurcher animals. Detailed genetic studies have allowed identification of Lc/Lc homozygotes prior to their death in the first postnatal day, and histologic studies of these animals indicate that Lurcher homozygotes are missing large neurons in several hindbrain nuclei. These studies establish that the Lurcher gene causes dose-dependent cell death of specific neuronal populations following their differentiation in the cerebellum and hindbrain." @default.
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- W62055145 date "1995-01-01" @default.
- W62055145 modified "2023-09-27" @default.
- W62055145 title "Lurcher, Cell Death and the Cell Cycle" @default.
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- W62055145 doi "https://doi.org/10.1007/978-3-642-79423-0_16" @default.
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