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- W62063735 abstract "Epidermal Growth Factor (EGF) is a small (6045 Dalton) protein that stimulates cell proliferation in both cell culture systems and in intact animals. EGF was first isolated from the submaxillary gland of the mouse by Cohen in 1962 [1]. Extracts of the gland when injected into newborn animals induced precocious eyelid opening and incisor eruption. At the time, Cohen was involved in research on Nerve Growth Factor but realized the potential importance of a substance with such profound biological effects. The biological response to injection of extracts of the submaxillary gland was due to a stimulation of epidermal growth and keratinization. The factor responsible for these effects was named Epidermal Growth Factor. The mouse EGF molecule contains 53 amino acid residues [2] and has disulphide bonds between cysteine residues 5 and 20, 14 and 31, 33 and 42, producing three disulphide loops in the secondary structure [3]. Mouse EGF is produced from a much larger precursor molecular of 130,000 Daltons [4]. In the mid 1970s, EGF was detected [5] and isolated from human urine [6]. In 1975 Gregory demonstrated that human EGF was equivalent to urogastrone, a hormone capable of inhibiting gastric acid secretion. Mouse EGF and urogastrone (Uro-EGF) share a 70% homology but are antigenically distinct as shown by radioimmunoassay [7]. They are, however, interchangeable in radioligand assays and growth stimulatory experiments." @default.
- W62063735 created "2016-06-24" @default.
- W62063735 creator A5003685480 @default.
- W62063735 creator A5018411240 @default.
- W62063735 date "1988-01-01" @default.
- W62063735 modified "2023-09-26" @default.
- W62063735 title "Epidermal growth factor receptors in human breast cancer" @default.
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- W62063735 doi "https://doi.org/10.1007/978-1-4613-1733-3_5" @default.
- W62063735 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/2908663" @default.
- W62063735 hasPublicationYear "1988" @default.
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