FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W620832811> ?p ?o ?g. }

• W620832811 abstract "Understanding the genetic basis of reproductive isolation is a fundamental question in evolution. In house mice, intrinsic postzygotic isolation via hybrid male sterility is emerging as a reoccurring pattern. Previous work has suggested that hybrid male sterility may be due to a disruption in meiotic sex chromosome inactivation (MSCI). MSCI is the process by which the sex chromosomes are transcriptionally silenced during the meiotic phase of spermatogenesis. It has been demonstrated that MSCI is necessary for successful spermatogenesis. Therefore, a disruption in the MSCI pathway may cause mismanagement of the sex chromosomes during spermatogenesis and thus may cause sterility. BRCA1, the tumor suppressor gene, has a vital role in the MSCI pathway and functions in a host of other cellular processes such as DNA double-stranded break (DSB) repair and X chromosome inactivation. We are taking a candidate gene approach in order to identify genes that may contribute to hybrid male sterility by evaluating patterns of molecular evolution in Mus musculus domesticus and Mus musculus musculus at genes implicated in MSCI. BRCA1 is a strong candidate for involvement in hybrid male sterility for this system because it is essential to the MSCI pathway and is highly divergent between M. m. musculus and M. m. domesticus. We sequenced exon 10 of BRCA1 in samples from wild populations of M. m. musculus (n = 20) and M. m. domesticus (n = 21). The sequence data were then analyzed with a variety of neutrality tests in order to detect positive selection. Positive selection acting on Brca1 in either lineage may lead to functional changes in the protein that are not compatible with the MSCI machinery in a hybrid background. Our results indicate that exon 10 of Brca1 is undergoing weak purifying selection in M. m. domesticus rather than positive selection. Therefore, there is no evidence in these data to suggest that exon 10 of the" @default.
• W620832811 created "2016-06-24" @default.
• W620832811 creator A5009505718 @default.
• W620832811 creator A5061114262 @default.
• W620832811 creator A5066425995 @default.
• W620832811 creator A5072575293 @default.
• W620832811 date "2011-05-01" @default.
• W620832811 modified "2023-09-24" @default.
• W620832811 title "BRCA1: A Candidate Gene for Reproductive Isolation in House Mice" @default.
• W620832811 cites W1514792623 @default.
• W620832811 cites W1538918049 @default.
• W620832811 cites W1599192329 @default.
• W620832811 cites W1966960717 @default.
• W620832811 cites W1971771310 @default.
• W620832811 cites W1972710550 @default.
• W620832811 cites W1982603712 @default.
• W620832811 cites W1984390786 @default.
• W620832811 cites W1986926802 @default.
• W620832811 cites W1989841784 @default.
• W620832811 cites W2003515720 @default.
• W620832811 cites W2011154623 @default.
• W620832811 cites W2012334640 @default.
• W620832811 cites W2025075293 @default.
• W620832811 cites W2025159855 @default.
• W620832811 cites W2031655127 @default.
• W620832811 cites W2035000127 @default.
• W620832811 cites W2035546417 @default.
• W620832811 cites W2037842315 @default.
• W620832811 cites W2052469882 @default.
• W620832811 cites W2060115431 @default.
• W620832811 cites W2062544730 @default.
• W620832811 cites W2064681322 @default.
• W620832811 cites W2068974811 @default.
• W620832811 cites W2082967637 @default.
• W620832811 cites W2087563853 @default.
• W620832811 cites W2088194699 @default.
• W620832811 cites W2097198780 @default.
• W620832811 cites W2111890991 @default.
• W620832811 cites W2116668053 @default.
• W620832811 cites W2121950969 @default.
• W620832811 cites W2121986040 @default.
• W620832811 cites W2124673802 @default.
• W620832811 cites W2132010230 @default.
• W620832811 cites W2133894023 @default.
• W620832811 cites W2139533668 @default.
• W620832811 cites W2140784970 @default.
• W620832811 cites W2140979516 @default.
• W620832811 cites W2145319723 @default.
• W620832811 cites W2148598128 @default.
• W620832811 cites W2151312508 @default.
• W620832811 cites W2162058527 @default.
• W620832811 cites W2163600007 @default.
• W620832811 cites W2167360238 @default.
• W620832811 cites W2505942523 @default.
• W620832811 cites W93588716 @default.
• W620832811 hasPublicationYear "2011" @default.
• W620832811 type Work @default.
• W620832811 sameAs 620832811 @default.
• W620832811 citedByCount "0" @default.
• W620832811 crossrefType "dissertation" @default.
• W620832811 hasAuthorship W620832811A5009505718 @default.
• W620832811 hasAuthorship W620832811A5061114262 @default.
• W620832811 hasAuthorship W620832811A5066425995 @default.
• W620832811 hasAuthorship W620832811A5072575293 @default.
• W620832811 hasConcept C104317684 @default.
• W620832811 hasConcept C144024400 @default.
• W620832811 hasConcept C148196450 @default.
• W620832811 hasConcept C149923435 @default.
• W620832811 hasConcept C26772143 @default.
• W620832811 hasConcept C2776687438 @default.
• W620832811 hasConcept C2908647359 @default.
• W620832811 hasConcept C54355233 @default.
• W620832811 hasConcept C69991583 @default.
• W620832811 hasConcept C86803240 @default.
• W620832811 hasConceptScore W620832811C104317684 @default.
• W620832811 hasConceptScore W620832811C144024400 @default.
• W620832811 hasConceptScore W620832811C148196450 @default.
• W620832811 hasConceptScore W620832811C149923435 @default.
• W620832811 hasConceptScore W620832811C26772143 @default.
• W620832811 hasConceptScore W620832811C2776687438 @default.
• W620832811 hasConceptScore W620832811C2908647359 @default.
• W620832811 hasConceptScore W620832811C54355233 @default.
• W620832811 hasConceptScore W620832811C69991583 @default.
• W620832811 hasConceptScore W620832811C86803240 @default.
• W620832811 hasLocation W6208328111 @default.
• W620832811 hasOpenAccess W620832811 @default.
• W620832811 hasPrimaryLocation W6208328111 @default.
• W620832811 hasRelatedWork W2004916637 @default.
• W620832811 hasRelatedWork W2138879539 @default.
• W620832811 hasRelatedWork W2154792078 @default.
• W620832811 isParatext "false" @default.
• W620832811 isRetracted "false" @default.
• W620832811 magId "620832811" @default.
• W620832811 workType "dissertation" @default.