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- W62110900 abstract "We have previously shown that rat mtGPAT has two promoters : a regulatory distal promoter which is ~ 30kb upstream of the first translational codon and a constitutive proximal promoter which is 63 bp upstream of the second translational codon. These promoters are responsible for the production of two transcripts with different 5′-ends. The tissue distribution of the two transcripts and the amount and specific activity of mtGPAT protein were investigated. 5'RACE PCR performed on total RNA isolated from different tissues of rat suggested the presence of alternatively spliced variants of the distal and proximal promoter products. There was presence of three spliced variants of mtGPAT mRNA in liver, kidney and adipose tissues while there was presence of only two variants in skeletal muscle, heart, lung and brain. Western blotting and GPAT specific activity performed on intact mitochondria isolated from the various tissues suggested that both the mtGPAT protein levels and their specific activities were relatively higher in liver, adipose tissues, heart, kidney and were much lower in the other tissues. The results also provide evidence that there is a constant level of the proximal transcript in all the tissues while the amount of the distal transcript varied in a tissue specific manner. Supported by NIH grant GM-57643." @default.
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- W62110900 date "2009-04-01" @default.
- W62110900 modified "2023-09-27" @default.
- W62110900 title "Distal and proximal promoters of rat mitochondrial glycerophosphate acyltransferase gene direct the tissue specific expression of their transcripts" @default.
- W62110900 doi "https://doi.org/10.1096/fasebj.23.1_supplement.495.3" @default.
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