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- W621291730 abstract "This chapter describes practical immunosensors for plasma protein monitoring. The immunosensors for fatty acid binding protein (FABP) and for apolipoprotein (apo) E have been developed. It is found that 1.5–3 h after the onset of the first clinical symptoms of acute myocardial infarction, the levels of heart FABP in plasma are significantly elevated up to 150 μg/ml. FABP is a remarkable new infarction marker. The normal plasma concentration of apo E can be increased up to 5times in certain pathological findings, such as familial type III hyperlipoproteinemia. apoE participates in the redistribution of cholesterol among cells, and may play a role in the pathogenesis of atherosclerosis. It is found that with a reusable immunosensor FABP could be determined in plasma samples, and quantified with high sensitivity reflecting exactly the time course of myocardial infarctions of different types. The values corresponded directly with those measured with ELISA. ApoE could be determined in plasma samples using monoclonal antibodies as catching antibodies with a detection limit of 20 ng/ml; thus exceeding by three orders of magnitude the normal value to be measured." @default.
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- W621291730 date "1994-01-01" @default.
- W621291730 modified "2023-09-27" @default.
- W621291730 title "Practical Immunosensors for Plasma Protein Monitoring" @default.
- W621291730 doi "https://doi.org/10.1016/b978-1-85617-242-4.50095-1" @default.
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