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- W621800548 abstract "Moderate prenatal alcohol exposure (PAE) in humans leads to learning and memory impairments later in life. The range of physical, behavioral, emotional, and social dysfunctions that are associated with PAE are collectively termed fetal alcohol spectrum disorder (FASD). It is estimated that approximately 12% of women consume alcohol at some time during their pregnancy and as many as 5% of children born in the United States are impacted by PAE. Extensive research has shown that even moderate maternal drinking (1-2 drinks per day) is, in some individuals, associated with cognitive and behavioral deficits. Existing models for PAE have been useful in studying the effects of moderate exposure, including its effect on hippocampal learning and memory; however, these models often include factors, such as stress or malnutrition issues, that can confound results. To date, most studies on the behavioral consequences of PAE have focused on overall hippocampal-dependent behavioral deficits, withouth attempting to determine whether the impairment may be attributed to altered functioning of a subregion (e.g. the" @default.
- W621800548 created "2016-06-24" @default.
- W621800548 creator A5040064695 @default.
- W621800548 date "2012-07-03" @default.
- W621800548 modified "2023-09-27" @default.
- W621800548 title "Prenatal Alcohol Exposure Effects on NMDA Receptor Subunit Composition and Function in the Mouse Dentate Gyrus" @default.
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