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- W622132105 abstract "Sprague-Dawley rats were exposed through intratracheal instillation, in accordance with an IACUC approved animal use protocol (ECBC protocol #07-395), to a low, medium or high dose of copper, aluminum or brass nanoflake, synthesized through a ball-milling procedure. At various time points post exposure the animals lungs were either recovered for histopathological analysis or broncheoalveolar lavaged for pro-inflammatory cytokine analysis or differntial cell count analysis. Our results have indicated a different mechanism of toxicological action based on the underlying chemistry of the instilled particulate. Specifically, the copper and brass nanoflakes are soluble under ambient lung conditions. This has led to the observation of an acutely inflammatory lung response following instillation of even low levels (0.1 mg/kg) of these nanoflakes within 24 hours post exposure; that is resolved by 14 days post exposure. The aluminum nanoflake is insoluble and therefore must undergo macrophage clearance from the lung following instillation. Interestingly, the kinetics of inflammatory reaction of the lung are much slower with the aluminum nanoflake and the observed response is increasing out to at least 14 days post exposure. This seems to indicate a more chronic problem associated with aluminum nanoflake exposure when compared to the acutely toxic response observed with copper and brass nanoflakes." @default.
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- W622132105 date "2009-04-01" @default.
- W622132105 modified "2023-09-27" @default.
- W622132105 title "Lung Pathology Following Instillation of Metal Nanoflake Particulates" @default.
- W622132105 doi "https://doi.org/10.1096/fasebj.23.1_supplement.lb346" @default.
- W622132105 hasPublicationYear "2009" @default.
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