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- W622425892 abstract "Background – Soluble dietary fibres (SDF), such as β-glucan and arabinoxylan have been reported to lower plasma cholesterol in the human body. They act by preventing bile salts (BS) from being reabsorbed from the distal ileum into the entrohepatic circulation and increasing BS concentration in the faeces.. In the hepatocyte, the bile acid (BA) pool is decreased causing the activation of cholesterol 7α-hydroxylase which in turn enhances the de novo synthesis of BA from the cholesterol intra-cellular pool. Consequently, cholesterol and low-density lipoprotein (LDL) receptors biosynthesis is increased, resulting in depletion of plasma cholesterol. However, mechanisms by which SDF interact with BS are yet to be defined sufficiently to identify optimal SDF characteristics.Objective – To test hypotheses for the action of SDF on BS, in order to identify important fibre characteristics.Design – Hypothesis 1: SDF forms a barrier between micelles & enterocytes. This will be tested by measuring the ability of BS micelles to cross a range of SDF-based gel barriers. Hypothesis 2: There is molecular binding between SDF & BS at a molecular level. This will be tested by NMR titration experiments. Hypothesis 3: BS micelles are entrapped in the SDF matrix. This will be tested by fluorescence and diffusion-ordered NMR spectroscopy.Outcomes – A practical method for studying the transport of bile salt mixed micelles through viscous solutions and gels of soluble dietary fibres has been developed. Transwell® inserts with a microporous (0.4 μm) membrane conventionally used for cell culture have been used as a support through which passage of micelles can be quantified.Analysis of arabinoxylan / bile salt micelle mixtures by 13C NMR shows no measurable change in bile salt chemical shift values, providing no evidence for direct molecular binding between the fibre and bile salts.Conclusion – Modern physico-chemical techniques can be used to test alternative hypotheses for the interaction of soluble dietary fibres with bile salt micelles, and help to identify optimal fibre sources for cholesterol reduction." @default.
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- W622425892 date "2008-01-01" @default.
- W622425892 modified "2023-09-27" @default.
- W622425892 title "Mechanisms behind the cholesterol-lowering effect of soluble dietary fibres" @default.
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