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- W622658051 abstract "Hypertriglyceridemia has been recognized as one of the risk factors in the development of atherosclerosis. But the mechanism by which VLDL act as atherogenic agents is not clear. It has been suggested that VLDL catabolism differed considerably when normal and hyperlipidemic subjects were compared. So in the present study we examined the composition and the nature of VLDL subfractions from hypertriglyceridemic subjects and normal.1. Human VLDLa) 39 hypertriglyceridemic subjects and 20 normal were examined.b) VLDL were subfractioned by heparin sepharose 4B affinity chromatography into heparin unbound fraction (VLDLa) and heparin bound fraction (VLDLb).c) VLDLb fraction contained relatively more cholesterol and less triglyceride than VLDLa fraction.d) Apoprotein analyses of VLDL subfractions were performed by SDS-polyacrylamide gel electrophoresis. Apo-E was rich in VLDLb but not in VLDLa.e) Particle size distributions of VLDL subfractions were examined by electron microscopy. VLDLa and VLDLb fractions from normal contained particles between 350-800Å (575±92Å) and 250-675Å (465±93Å) in diameter respectively.f) The percentage of VLDLb in the d<1.006 fraction was significantly higher in hypertriglyceridemic subjects than normal. (88±8.4%, 74±14%, p<0.001)g) Positive correlations existed in the % of VLDLb vs. plasma TG and the % of VLDLb vs. VLDL-TG. (r=0.305 p<0.05, r=0.509 p< 0.001)2. Rat VLDLExperimental hypertriglyceridemia was prodused by the feeding of 10% fructose containing solution for 2-4 ws. VLDL subfractions were examined in 10 hypertriglyceridemic and 8 control rats.a) The % of VLDLb was also significantly higher in hypertriglyceridemic rats than control.b) Positive correlations between the % of VLDLb vs. plasma TG and the % of VLDL vs. VLDL-TG were also observed.It was suggested that VLDLb, which were smaller in size, depleted in triglyceride, and relatively rich in cholesterol and apo-E, might contribute to the development of atherosclerosis." @default.
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- W622658051 date "1983-01-01" @default.
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- W622658051 title "Subfractionation of VLDL from Hypertriglyceridemic Subjects and Normal by Heparin Sepharose 4B Affinity Chromatography" @default.
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- W622658051 doi "https://doi.org/10.5551/jat1973.11.1_57" @default.
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