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- W622762337 abstract "Alkaloids are very important natural products. Most of them have biologic activity. Many novel drugs have been developed based on alkaloids, such as camptothecin, taxol, vinblastine. A series of novel cryptolepine derivatives were synthesized (Figure 1). The interaction of cryptolepine derivatives with G-quadruplex (Figure 2) was studied by CD and UV spectra.[1] Most of these compounds can induce the formation of G-quadruplex and stabilize the formed G-quadruplex, resulting in the inhibitory effect on telomerase. Most of these cryptolepine derivatives have potent cytotoxicity in vitro against human tumor cell line.……" @default.
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- W622762337 date "2004-01-01" @default.
- W622762337 modified "2023-09-23" @default.
- W622762337 title "Cryptolepine Derivatives: Quadruplex-Interactive Agents as Inhibitors of Human Telomerase" @default.
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